Creatine and Creatinine Metabolism

TL;DR: Dietary cyclocreatine tempered autophagy, restored microglial clustering around plaques, and decreased plaque-adjacent neuronal dystrophy in TREM2-deficient mice with amyloid-β pathology, finding that TREM1 enables microglia responses during AD by sustaining cellular energetic and biosynthetic metabolism.

TL;DR: Experiments demonstrated that T cells from GCN2 knock-out mice did not show a decreased proliferation and were able to up-regulate cyclin D3 when cultured in the absence of L-Arg, contributing to the understanding of a central mechanism by which cancer and other diseases characterized by high arginase I production may cause T-cell dysfunction.

TL;DR: The crop plant model rice ( Oryza sativa) is used here as an example to highlight mechanisms and genes for adaptation of crop plants to drought stress.

TL;DR: It is demonstrated that creatine enhances respiration in beige-fat mitochondria when ADP is limiting and decreases whole-body energy expenditure after administration of a β3-agonist and reduces beige and brown adipose metabolic rate.

TL;DR: Assays are now available to follow changes during metabolic stresses of any combination or all of the following phosphagens accumulated by the same tissue: creatine-P, N-ethylguanidinoacetate-p, cyclocreatine-P , N-methyl-3-guanodinopropionate-P and homocyclocreatin-P.

TL;DR: Effect of creatine depletion by beta-guanidinopropionic acid (beta-GPA) feeding on mitochondrial morphology was studied in rats and intramitochondrial inclusions running parallel to the long axis of mitochondrion were observed in skeletal muscles.

TL;DR: Phorphorus NMR spectra of the whole reproductive organs of male rats and their perchloric acid extracts indicate the presence of phosphocholine and phosphoethanolamine in the testis, glycerophosphocholine (GPC) and glycerophonine (GPE) in the epididymis, and creatine phosphate, GPC, and GPE in the seminal vesicles.

TL;DR: This finding suggests that the detection of a high number of ACF with low crypt multiplicity in mice colon after IQ- or PhIP-treatment is not indicative for the end-point colon cancer, and supports the hypothesis that only the presence of ahigh number ofACF with high crypt multiplier is predictive for tumor outcome.