Journal Article10.1126/science.abn1755
COVID-19 vaccination: The road ahead
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TL;DR: A diverse array of successful, first-generation SARS-CoV-2 vaccines have played a huge role in efforts to bring the COVID-19 pandemic under control, even though inequitable distribution still leaves many vulnerable.
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Abstract: A diverse array of successful, first-generation SARS-CoV-2 vaccines have played a huge role in efforts to bring the COVID-19 pandemic under control, even though inequitable distribution still leaves many vulnerable. Additional challenges loom for the next phase. These include optimizing the immunological rationale for boosting—how often and with what—and the best approaches for building a future-proofed, durable immune repertoire to protect against oncoming viral variants, including in children. The landscape of vaccine producers and technologies is likely to become even more heterogeneous. There is a need now for appraisal of future approaches: While some favor frequent boosting with the first-generation, ancestral spike vaccines, others propose frequent readjustment using current variant sequences, polyvalent vaccines, or pan-coronavirus strategies. Description
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Citations
Psychological Aspects, Psychodermatology, and Vaccine Hesitancy During the COVID-19 Pandemic
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TL;DR: A series of chimeric miniproteins that mimic two different half subdomains of HR1 that could inhibit cell infection by SARS-COV-2 real viruses in cell cultures and the inhibitory activity of the miniproteins correlated with their structural stability, but not with their relative binding affinity for HR2 peptides.
Additional file 1 of Detection of IgG antibodies against the receptor binding domain of the spike protein and nucleocapsid of SARS-CoV-2 at university students from Southern Mexico: a cross-sectional study
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Abstract: Supplementary Material 1
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Sihui Zhang,Mingting Wang,Linyi Chen,Juan Wang,Y. F. Yu,Liandi Tao,Xiaoxia Xu,Jing Luo,Chao Wang,Juan Du,Yaqiong Liu,Qing-Bin Lu,Fuqiang Cui +12 more
TL;DR: Differences in vaccination consultation preferred by primary health care workers and residents in community settings reveal a gap between providers and demanders, highlighting the need for targeted interventions and resource allocation strategies.
The Limitations of a Hypothetical All-Variant COVID-19 Vaccine: A Simulation Study
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