1. What are the contributions in "Corticosteroid therapy for critically ill patients with the middle east respiratory syndrome" ?
In this paper, the authors investigate the association of corticosteroid therapy on mortality and on MERS-CoV RNA clearance accounting for potential immortaltime bias and indication bias.
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2. Why was the rRT-PCR testing not performed in the first week?
Because of the retrospective observational nature of ourstudy, repeat rRT-PCR testing was not protocolized and varied among centers.
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3. What is the role of data acquisition in the work?
AH: Data acquisition, critical revision of the manuscript for important intellectual content, approval of the final version to be published and agreement to be accountable for all aspects of the work.
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4. How did the authors model the effect of corticosteroid therapy on mortality?
Marginal Structural Cox proportional hazards modelMarginal Structural Cox proportional hazard model was carried outincorporating the stabilized weights to estimate the effect of corticosteroid therapy onMERS-CoV RNA clearance in a similar approach to the marginal structural modelused for 90-day mortality above.
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