Correlation of End Tidal CO2 (ETCO2) Level with Hyperlactatemia in Patient with Hemodynamic Disturbance
Made Wiryana,I Ketut Sinardja,I GedeBudiarta,Img Widnyana,Wayan Aryabiantara,AA Ayu Wulan Paramasari +5 more
TL;DR: ETO2 was related to serum lactate level in patients with hemodynamic disturbance and was hypothesized as related to hyperlactatemia, thus monitoring of ETCO2 could be a non-invasive monitoring in hemodynamically unstable patients.
read more
Abstract: Background: Critically ill and hemodynamically unstable patients usually have perfusion disturbance that causes anerobic metabolism, causing increased lactate production. Hyperlactatemia induces metabolic acidosis, which then compensated by hyperventilation. Decreased PaCO2 as the consequence of hyperventilation can be measured as end-tidal CO2 (ETCO2). High ETCO2 was hypothesized as related to hyperlactatemia, thus monitoring of ETCO2 could be a non-invasive monitoring in hemodynamically unstable patients.
Objective: This study aimed to search the correlation between ETCO2 level and hyperlactatemia in patients with hemodynamic disturbance.
Method: This was observational, cross sectional study conducted on January to February 2017 in Sanglah General Hospital, Bali, Indonesia. Subjects were hemodinamicaly unstable patients aged 13-90 years old without primary pulmonary diseases recruited by consecutive sampling. ETCO2 measurement by capnograph, lactate level measurement, and blood good analysis were done to all eligible patients. We did an association test to determine ther relation between ETCO2 level and lactate level in such patients.
Results: There were 70 subjects analyzed with median age 55 years old. Subjects’ case was 35.7% called for resuscitation, 32.9% was septic shock with surgery, 17.1% was septic shock without surgery, and 14.3% was hypovolemic shock with surgery. Most of most of the patients had compensated metabolic acidosis (82.9%). Correlation analysis between ETCO2 and lactate level showed significantly strong negative correlation (correlation coefficient [r]=-0.852, p=0.001). Linear regression analysis of correlation showed that an increase of 1 mmol/L lactate was associated with decrease of 3.42 mmol/L ETCO2 (p<0.001).
Conclusion: ETCO2 was related to serum lactate level in patients with hemodynamic
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Relationship between End-Tidal CO2 (ETCO2) and Lactate and their Role in Predicting Hospital Mortality in Critically Ill Trauma Patients; A Cohort Study.
Elham Safari,Mehdi Torabi +1 more
TL;DR: ETCO2 post-intubation and serum lactate may be considered as prognostic factors for intubated multiple trauma patients referring to the emergency department, which can give the clinician an important clue in early prediction of the hospital mortality.
8
To what extent is end-tidal carbon dioxide a predictor of sepsis?
Joseph Long,Enrico Dippenaar +1 more
TL;DR: This review suggests an EtCO2 of ≤25 mmHg (3.3 kPa) in patients with a suspected infection is diagnostic of sepsis and therefore could be used to increase the speed and accuracy of diagnosis and potentially reduce sepsi mortality.
Assessing the Utility of End-Tidal Carbon Dioxide as a Marker for Fluid Responsiveness in Cardiogenic Shock.
Komal Baloch,Aziz Rehman Memon,Urwah Ikhlaq,Madiha Umair,Muhammad Imran Ansari,Jawed Abubaker,Nawal Salahuddin +6 more
TL;DR: In this paper, the discriminant power of changes in end-tidal carbon dioxide (ETCO2), systolic blood pressure (SBP), inferior vena cava (IVC), and venous to arterial carbon dioxide gap after a fluid challenge was compared to increases in cardiac output.
A comparative study between serum lactate level versus change in end tidal carbon dioxide level regarding assessment of hemodynamic instability in intensive care unit patients after cardiac surgeries
Ahmed Esam Omar Ibrahim,Mohamed Sidky Mahmoud Zaki,Sarah Ahmed Salem Ahmed,Rania Maher Hussien Maamoon +3 more
References
Serum lactate is a useful predictor of death in severe sepsis and septic shock
TL;DR: An independent review of the literature includes 83 studies published in all electronic-based database such as Elsevier, PubMed, and SID during the last 18 years and found serum lactate was associated with mortality independent of clinically apparent organ dysfunction and shock in patients with severe sepsis admitted to the emergency department and intensive care unit.
17
Arterial to ETCo2 difference in patients with acute renal failure
Rozbeh Rajaei Ghafori,Ali Taghizadieh,Nafiseh Farhan,Jalal Etemadi,Hassan Solimanpoor,Farzad Rahmani,Mohammad Mirzaaghazadeh +6 more
- 01 Jan 2014
TL;DR: Investigation of the relationship between the levels of end-tidal carbon dioxide acidosis with acidosis level in patients with acute renal failure found significant direct liner correlation between Co2 level with Capnography with PH, PCo2, HCo3 and BE level in ABG.
2
Evaluation of end-tidal carbon dioxide role in predicting elevated SOFA scores and lactic acidosis.
TL;DR: A small, but statistically significant correlation, is found between ETCO2 and SOFA scores; however, based on questionable operating characteristics, the test seems to have limited ability to meaningfully impact clinical decision making.