Open AccessJournal Article
Correlation of DNA ploidy with c-erbB-2 expression in preinvasive and invasive breast tumors.
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TL;DR: Oncogene product expression and DNA content derangements may be related biologic parameters in breast neoplasia, and both are highly associated with cytologic nuclear abnormalities.
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Abstract: Detection of c-erbB-2 oncogene product expression by monoclonal antibody staining (avidin-biotin technique) in formalin-fixed, paraffin-embedded atypical hyperplasias (AH, n = 20), intraductal carcinomas (IDCA, n = 27) and invasive carcinomas (INVCA, n = 48) was compared to ploidy determinations obtained by flow cytometry (INVCA) or image analysis (AH, IDCA). Cytoplasmic membrane staining was present in 11/48 (23%) INVCA and 8/27 (30%) IDCA but none of the AH. Tumors with abnormal DNA content expressed c-erbB-2 more frequently: INVCA, 2/19 (11%) diploid range versus 9/29 (31%) aneuploid; IDCA, 1/7 (14%) diploid range versus 7/20 (35%) aneuploid. Poorly differentiated (nuclear grade) IDCA or INVCA were also more frequently stained (14/35, 40%) than were well or moderately differentiated cases (5/40, 12.5%). Oncogene product expression and DNA content derangements may be related biologic parameters in breast neoplasia, and both are highly associated with cytologic nuclear abnormalities.
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TL;DR: In this paper, the authors examined the receptor status and the histological grade in Chinese DCIS patients to identify any independent predictor in order to discriminate a subgroup with coexisting invasion from pure DCIS.
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Aneuploidy in Breast Cancer: A Fluorescence In Situ Hybridization Study
Stanley E. Shackney,Sarita G. Singh,Robert Yakulis,Charles A. Smith,Agnese A. Pollice,Susan Petruolo,Alan S. Waggoner,Robert J. Hartsock +7 more
TL;DR: The FISH data suggested that aneuploidy arises by a process of chromosome complement doubling with subsequent chromosome loss, and in tumors that exhibited evidence of more than one round of chromosomes complement doubling, the selective accumulation of multiple copies of specific chromosomes or chromosome segments was common.
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Genetic markers as prognostic indicators in breast cancer.
Sandra R. Wolman,Robert J. Pauley,Anwar N. Mohamed,Peter J. Dawson,Daniel W. Visscher,Fazlul H. Sarkar +5 more
TL;DR: Currently, to the authors' knowledge, none has shown uniform changes by mutation, loss, or overexpression in all breast cancers, although a remarkable number of loci are altered to some extent.
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