Open AccessJournal Article
Correlation between Vitamin D receptor gene FOKI and BSMI polymorphisms and the susceptibility to pulmonary tuberculosis in an Indonesian Batak-ethnic population.
TL;DR: In Indonesian Batak ethnic population, there was no association between FokI polymorphism of VDR gene with host susceptibility to PTB and there was a significant association between BsmI genotype and PTB; the bb genotype was associated with a decreased risk toPTB.
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Abstract: Aim : to explore the role of FokI and BsmI polymorphisms the VDR gene in the susceptibility to pulmonary tuberculosis (PTB) in an Indonesian Batak ethnic population. Methods : matched case-control study was conducted on 76 PTB patients and 76 healthy normal control. Genetic polymorphisms of Vitamin D Receptor (VDR) gene were analysed using PCR-RFLP. Results : the frequencies of FokI genotypes were FF 35.5%, Ff 55.3%, ff 9.2% for PTB patients and FF 39.5%, Ff 44.7.% and ff 15.8% for normal control. The BsmI genotypes frequencies were BB 0%, Bb 68.4%, bb 31.6% for TB patients and BB 2.6%, Bb 23.7% and bb 73.7% for control. There was no significant association between FokI genotype and PTB (OR 1.39, 95% CI: 0.69-2.77 for Ff genotype and OR 0.64, 95% CI: 0.22-1.86 for ff genotype). There was a significant association between BsmI genotype and PTB; the bb genotype was associated with a decreased risk to PTB (OR 0.22, 95% CI: 0.11-0.45). Conclusion : in Indonesian Batak ethnic population, there was no association between FokI polymorphism of VDR gene with host susceptibility to PTB. There was a significant association between BsmI polymorphism of VDR gene; bb genotype was associated with a decreased risk to PTB. Key words : pulmonary tuberculosis, polymorphisms, vitamin D receptor gene, Batak, Indonesia
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Citations
The Role of Host Genetics (and Genomics) in Tuberculosis.
TL;DR: The heritability of TB is reviewed, the host genetic and transcriptomic correlates of disease are reviewed, and current studies and future prospects in the study of host genomics in TB are highlighted.
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Genomics of Human Pulmonary Tuberculosis: from Genes to Pathways
Catherine M. Stein,Lindsay N. Sausville,Christian Wejse,Rafal S. Sobota,Nicola M. Zetola,Nicola M. Zetola,Philip C. Hill,W. Henry Boom,William K. Scott,Giorgio Sirugo,Scott M. Williams +10 more
TL;DR: A pathway-based extension of standard association analyses is presented, seeding the results with the best validated genes from candidate gene and genome-wide association studies, to help explain population patterns of TB risk.
Vitamin D Receptor Gene FokI Polymorphism Contributes to Increasing the Risk of Tuberculosis: An Update Meta-Analysis
TL;DR: It is confirmed that VDR FokI polymorphism contributes to the risk of TB, especially in HIV-negative TB patients and in the Asian group.
36
NRAMP1 and VDR Gene Polymorphisms in Susceptibility to Tuberculosis in Venezuelan Population
TL;DR: The results suggest the absence of any association between VDR variants FokI, ApaI, and TaqI and susceptibility to tuberculosis and the NRAMP1 3′UTR variants were associated with susceptibility to M. tuberculosis infection and disease progression.
A reappraised meta-analysis of the genetic association between vitamin D receptor BsmI (rs1544410) polymorphism and pulmonary tuberculosis risk.
Mohammed Y. Areeshi,Raju K. Mandal,Sajad Ahmad Dar,Sajad Ahmad Dar,Abdulrahman Alshahrani,Aqeel Ahmad,Arshad Jawed,Arshad Jawed,Mohd Wahid,Mohtashim Lohani,Aditya K. Panda,Shafiul Haque +11 more
TL;DR: VDR BsmI polymorphism is not a risk factor for PTB in overall population, however, this polymorphism may be interrelated to an increased risk of PTB amongst Asians.
References
Vitamin D Receptor Polymorphisms and Susceptibility to Tuberculosis in West Africa: A Case-Control and Family Study
Liza Bornman,Sarah J. Campbell,Katherine Fielding,Boubacar Bah,Jackson Sillah,Per Gustafson,Kebba Manneh,Ida Lisse,Angela Allen,Giorgio Sirugo,Aissatou Sylla,Peter Aaby,Keith P. W. J. McAdam,Oumou Bah-Sow,Steve Bennett,Christian Lienhardt,Adrian V. S. Hill +16 more
TL;DR: The significance of the family-based associations found between TB and FokI-BsmI-ApaI-TaqI and the FA haplotype supports a role for VDR haplotypes, rather than individual genotypes, in susceptibility to TB.
•Journal Article
VDR and NRAMP1 gene polymorphisms in susceptibility to pulmonary tuberculosis among the Chinese Han population: a case-control study.
W Liu,W C Cao,C Y Zhang,L Tian,X M Wu,J D F Habbema,Q M Zhao,P H Zhang,Z T Xin,C Z Li,H Yang +10 more
TL;DR: Polymorphisms in the VDR and NRAMP1 gene are statistically associated with susceptibility to PTB in the Chinese Han population and neither univariate nor multivariate analysis disclosed any significant association between the disease and TaqI or INT4.
Genetic Epidemiology of Tuberculosis Susceptibility: Impact of Study Design
TL;DR: Important differences in phenotype definition in both cases and controls, consideration of latent M. tuberculosis infection versus active TB disease, population genetic factors such as population substructure and linkage disequilibrium, polymorphism selection, and potential global differences in M.culosis strain are illustrated.
Vitamin D receptor gene polymorphisms on the risk of tuberculosis, a meta-analysis of 29 case-control studies.
TL;DR: It is concluded that variants of the VDR gene that are homozygous for the FokI polymorphism might be more susceptible to tuberculosis in Chinese and larger sample studies are warranted to confirm the protective effects of BsmI variants on tuberculosis in the Europeans.
Infection with Mycobacterium tuberculosis Beijing Genotype Strains Is Associated with Polymorphisms in SLC11A1/NRAMP1 in Indonesian Patients with Tuberculosis
Reinout van Crevel,Ida Parwati,Edhyana Sahiratmadja,Sangkot Marzuki,Tom H. M. Ottenhoff,Mihai G. Netea,André J. A. M. van der Ven,R.H.H. Nelwan,Jos W. M. van der Meer,Bachti Alisjahbana,Esther van de Vosse +10 more
TL;DR: The M. tuberculosis Beijing genotype, which comprised 29.8% of all isolates, was strongly associated with 2 polymorphisms in SLC11A1: the D543N G allele (odds ratio [OR], 2.15) and the 3' untranslated region (3'UTR) insertion/insertion genotype (OR, 2.5; P=.001).