Open AccessJournal Article
Correlation between Vitamin D receptor gene FOKI and BSMI polymorphisms and the susceptibility to pulmonary tuberculosis in an Indonesian Batak-ethnic population.
TL;DR: In Indonesian Batak ethnic population, there was no association between FokI polymorphism of VDR gene with host susceptibility to PTB and there was a significant association between BsmI genotype and PTB; the bb genotype was associated with a decreased risk toPTB.
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Abstract: Aim : to explore the role of FokI and BsmI polymorphisms the VDR gene in the susceptibility to pulmonary tuberculosis (PTB) in an Indonesian Batak ethnic population. Methods : matched case-control study was conducted on 76 PTB patients and 76 healthy normal control. Genetic polymorphisms of Vitamin D Receptor (VDR) gene were analysed using PCR-RFLP. Results : the frequencies of FokI genotypes were FF 35.5%, Ff 55.3%, ff 9.2% for PTB patients and FF 39.5%, Ff 44.7.% and ff 15.8% for normal control. The BsmI genotypes frequencies were BB 0%, Bb 68.4%, bb 31.6% for TB patients and BB 2.6%, Bb 23.7% and bb 73.7% for control. There was no significant association between FokI genotype and PTB (OR 1.39, 95% CI: 0.69-2.77 for Ff genotype and OR 0.64, 95% CI: 0.22-1.86 for ff genotype). There was a significant association between BsmI genotype and PTB; the bb genotype was associated with a decreased risk to PTB (OR 0.22, 95% CI: 0.11-0.45). Conclusion : in Indonesian Batak ethnic population, there was no association between FokI polymorphism of VDR gene with host susceptibility to PTB. There was a significant association between BsmI polymorphism of VDR gene; bb genotype was associated with a decreased risk to PTB. Key words : pulmonary tuberculosis, polymorphisms, vitamin D receptor gene, Batak, Indonesia
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Vitamin D Receptor Gene FokI Polymorphism Contributes to Increasing the Risk of Tuberculosis: An Update Meta-Analysis
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NRAMP1 and VDR Gene Polymorphisms in Susceptibility to Tuberculosis in Venezuelan Population
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A reappraised meta-analysis of the genetic association between vitamin D receptor BsmI (rs1544410) polymorphism and pulmonary tuberculosis risk.
Mohammed Y. Areeshi,Raju K. Mandal,Sajad Ahmad Dar,Sajad Ahmad Dar,Abdulrahman Alshahrani,Aqeel Ahmad,Arshad Jawed,Arshad Jawed,Mohd Wahid,Mohtashim Lohani,Aditya K. Panda,Shafiul Haque +11 more
TL;DR: VDR BsmI polymorphism is not a risk factor for PTB in overall population, however, this polymorphism may be interrelated to an increased risk of PTB amongst Asians.
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The association between BsmI variant of vitamin D receptor gene and susceptibility to tuberculosis
TL;DR: The present study results suggest that BsmI variant of VDR gene may play an important role in susceptibility to tuberculosis.
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Vitamin D receptor gene variants of BsmI, ApaI, TaqI, and FokI polymorphisms in spinal tuberculosis.
TL;DR: Spinal tuberculosis [an extrapulmonary form of TB] is a degenerative disease of the spine caused by Mycobacterium tuberculosis, known as Pott’s disease.
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SLC11A1 and VDR gene variants and susceptibility to tuberculosis and disease progression in East India.
TL;DR: This study, the first to include evidence on 577G/A and INT4, reports a significant association between SLC11A1 gene variants and PTB with respect to susceptibility and subsequent disease progression in East India.
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Vitamin D receptor homozygote mutant tt and bb are associated with susceptibility to pulmonary tuberculosis in the Iranian population.
Mohammad Mehdi Banoei,Mehdi Mirsaeidi,Massoud Houshmand,Payam Tabarsi,Golnaz Ebrahimi,Laleh Zargari,Baharak Houshiar Kashani,Mohammad Reza Masjedi,S D Mansouri,Julio A. Ramirez +9 more
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Vitamin D Receptor Gene TaqI, BsmI and FokI Polymorphisms in Korean Patients with Tuberculosis
Tae Jin Kang,Song Hou Jin,Chung-Eun Yeum,Seong Beom Lee,Chi Hong Kim,Sang Haak Lee,Kwan Hyoung Kim,Eun-Soon Shin,Gue-Tae Chae +8 more
TL;DR: Three polymorphisms (TaqI, BsmI and FokI) in the VDR gene do not appear to be responsible for host susceptibility to human tuberculosis in Korean population.