Journal Article10.1007/S00330-017-4993-7
Correlation between conventional MR imaging combined with diffusion-weighted imaging and histopathologic findings in eyes primarily enucleated for advanced retinoblastoma: a retrospective study.
Yanfen Cui,Yanfen Cui,Ran Luo,Ruifen Wang,Huanhuan Liu,Caiyuan Zhang,Zhongyang Zhang,Dengbin Wang +7 more
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TL;DR: Conventional MRI has some limitations in reliably predicting microscopic infiltration, with the diagnostic efficiency showing room for improvement, whereas ADC values correlated well with certain high-risk prognostic parameters for retinoblastoma.
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Abstract: To determine the diagnostic accuracy of conventional MRI in detecting tumour invasion of advanced intraocular retinoblastoma and to correlate ADC values with high-risk prognostic parameters. The sensitivities, specificities, positive predictive values (PPV), negative predictive values (NPV) and accuracies of MRI in detecting tumour-extent parameters of 63 retinoblastomas were determined. Furthermore, ADC values were correlated with high-risk prognostic parameters. MRI detected postlaminar optic nerve with a sensitivity of 73.3% (95% CI 44.9–92.2%) and a specificity of 89.6% (77.3–96.5%), while the specificity for choroidal invasion was only 31.8% (13.9-54.9%). Likewise, MRI failed to predicted early optic nerve invasion in terms of low sensitivity and PPV. In contrast, scleral and ciliary body invasion could be correctly excluded with high NPV. ADC values were significantly lower in patients with undifferentiated tumours, large tumour size, as with optic nerve and scleral invasion (all p < 0.05). However, no correlation was found between ADC values and the degree of choroidal or ciliary body infiltration. Additionally, ADC values were negatively correlated with Ki-67 index (r = −0.62, P = 0.002). Conventional MRI has some limitations in reliably predicting microscopic infiltration, with the diagnostic efficiency showing room for improvement, whereas ADC values correlated well with certain high-risk prognostic parameters for retinoblastoma. • Conventional MRI failed to predicted microscopic infiltration of the retinoblastoma. • Scleral and ciliary body invasion could be excluded with high NPV. • ADC values correlated well with some high-risk pathological prognostic parameters.
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Citations
Retinoblastoma: What the Neuroradiologist Needs to Know.
TL;DR: In this article, the authors discuss the clinical presentation of retinoblastoma, ophthalmic imaging modalities, neuroradiology imaging features, and current treatment options.
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Contemporary management of retinoblastoma in the context of a low-resource country.
TL;DR: Algorithm for management and development of the national RB program within the context of a low-resource country is presented from review of data extracted from Mendeley library, PubMed library, Google Scholar and One Network.
15
Diagnostic performance of MRI of post-laminar optic nerve invasion detection in retinoblastoma: A systematic review and meta-analysis.
TL;DR: MR imaging was demonstrated to have acceptable diagnostic performance in detecting PLONI in patients with RB and the variation in the magnetic field strength and protocols was the main factor behind the heterogeneity across the included studies.
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Anterior chamber enhancement predicts optic nerve infiltration in retinoblastoma
Katerina Deike-Hofmann,Paula von Lampe,Maija Eerikaeinen,Saskia Ting,S. Schlüter,Heinz Peter Schlemmer,Nikolaos E. Bechrakis,Michael Forsting,Alexander Radbruch +8 more
TL;DR: In this article , the authors used signal intensity ratios (∆SIRs) of the anterior eye chamber (AC) to the lens to predict retinoblastoma (RB) invasion.
High Resolution MR Imaging guidelines in retinoblastoma: prospective study correlated with histopathological results
TL;DR: High-resolution ocular MR imaging can reliably detect postlaminar optic nerve invasion, choroid, and extrascleral invasion; meanwhile, it shows low sensitivity inPreoperative magnetic resonance (MR) imaging diagnostic merits and indices in patients with retinoblastoma.
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STARD 2015: An Updated List of Essential Items for Reporting Diagnostic Accuracy Studies.
Patrick M.M. Bossuyt,Johannes B. Reitsma,David E. Bruns,Constantine Gatsonis,Paul Glasziou,Les Irwig,Jeroen G. Lijmer,David Moher,David Moher,Drummond Rennie,Henrica C.W. de Vet,Herbert Y. Kressel,Nader Rifai,Robert M. Golub,Douglas G. Altman test,Lotty Hooft,Daniël A. Korevaar,Jérémie F. Cohen,Jérémie F. Cohen +18 more
TL;DR: An updated list of 30 essential items that should be included in every report of a diagnostic accuracy study is presented, which incorporates recent evidence about sources of bias and variability in diagnostic accuracy and is intended to facilitate the use of STARD.
STARD 2015: An Updated List of Essential Items for Reporting Diagnostic Accuracy Studies.
Patrick M.M. Bossuyt,Johannes B. Reitsma,David E. Bruns,Constantine Gatsonis,Paul Glasziou,Les Irwig,Jeroen G. Lijmer,David Moher,David Moher,Drummond Rennie,Henrica C.W. de Vet,Herbert Y. Kressel,Nader Rifai,Robert M. Golub,Douglas G. Altman test,Lotty Hooft,Daniël A. Korevaar,Jérémie F. Cohen +17 more
TL;DR: An updated list of 30 essential items that should be included in every report of a diagnostic accuracy study is presented, which incorporates recent evidence about sources of bias and variability in diagnostic accuracy and is intended to facilitate the use of STARD.
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Intraocular retinoblastoma: the case for a new group classification.
TL;DR: The case for the creation of a new group classification of intraocular retinoblastoma is argued, based on the natural history and the risk of loss of the eye following primary therapy, against the current Reese-Ellsworth group classification.
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Corticosteroid-induced ocular hypertension and glaucoma: a brief review and update of the literature.
Relief Jones,Douglas J. Rhee +1 more
TL;DR: The literature pertaining to glaucoma in response to intravitreal triamcinolone acetonide will be reviewed, and the mechanism of elevated intraocular pressure is increased aqueous outflow resistance owing to an accumulation of extracellular matrix material in the trabecular meshwork.
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Guidelines for imaging retinoblastoma: imaging principles and MRI standardization
Pim de Graaf,Sophia Göricke,Firazia Rodjan,Paolo Galluzzi,Philippe Maeder,Jonas A. Castelijns,Hervé Brisse +6 more
TL;DR: Implementation of a standardized MRI protocol for retinoblastoma in clinical practice may benefit children worldwide, especially those with hereditary retinOBlastoma, since a decreased use of CT reduces the exposure to ionizing radiation.