Correction: New Maximum Likelihood Estimators for Eukaryotic Intron Evolution
TL;DR: The URL provided for the GPCR model database in the published article is no longer active and is now located at http://cssb.biology.gatech.edu/skolnick/files/gpcr/GPcr.html.
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Abstract: Correction: Structure Modeling of All Identified G Protein–Coupled Receptors in the Human Genome Yang Zhang, Mark E. DeVries, Jeffrey Skolnick DOI: 10.1371/journal.pcbi.0020013 In PLoS Computational Biology, volume 2, issue 2: The URL provided for the GPCR model database in the published article is no longer active. The database is now located at http://cssb.biology.gatech.edu/skolnick/files/gpcr/gpcr.html.
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Alternative splicing and evolution: diversification, exon definition and function.
TL;DR: The current knowledge of alternative splicing and evolution is summarized and insights into some of these unresolved questions are provided.
The function of introns.
Michal Chorev,Liran Carmel +1 more
TL;DR: It is shown that introns in contemporary species fulfill a broad spectrum of functions, and are involved in virtually every step of mRNA processing, and it is proposed that this great diversity of intronic functions supports the notion that intrins were indeed selfish elements in early eukaryotes, but then independently gained numerous functions in different eUKaryotic lineages.
Three distinct modes of intron dynamics in the evolution of eukaryotes
TL;DR: A comprehensive probabilistic model to obtain a definitive reconstruction of intron evolution was developed and applied to 391 sets of conserved genes from 19 eukaryotic species, inferring that a relatively high intron density was reached early.
Comparative genomic analysis of fungal genomes reveals intron-rich ancestors
TL;DR: This work finds strong support for an intron-rich fungus-animal ancestor, with more than four introns per kilobase, comparable to the highest known modern intron densities.
157
Coevolution of genomic intron number and splice sites.
TL;DR: It seems that eukaryotic ancestors had relatively large intron numbers and 'weak' 5'ss, a pattern associated with frequent alternative splicing in modern organisms.
111
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