Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of Anti-SARS Drugs
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New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CLpro inhibitors
Thomas Regnier,Diganta Sarma,Koushi Hidaka,Usman Bacha,Ernesto Freire,Yoshio Hayashi,Yoshio Hayashi,Yoshiaki Kiso +7 more
TL;DR: A series of trifluoromethyl, benzothiazolyl or thiazolyL ketone-containing peptidic compounds as SARS-CoV 3CL protease inhibitors were developed and their potency was evaluated by in vitro protease inhibitory assays.
55
A blueprint for high affinity SARS-CoV-2 Mpro inhibitors from activity-based compound library screening guided by analysis of protein dynamics
Jonas Gossen,Jonas Gossen,Simone Albani,Simone Albani,Anton Hanke,Anton Hanke,Benjamin P. Joseph,Benjamin P. Joseph,Cathrine Bergh,Maria Kuzikov,Elisa Costanzi,Candida Manelfi,Paola Storici,Philip Gribbon,Andrea R. Beccari,Carmine Talarico,Francesca Spyrakis,Erik Lindahl,Erik Lindahl,Andrea Zaliani,Paolo Carloni,Rebecca C. Wade,Rebecca C. Wade,Rebecca C. Wade,Francesco Musiani,Daria B. Kokh,Giulia Rossetti +26 more
- 16 Mar 2021
TL;DR: In this article, Zhang et al. defined the consensus chemical space arising from the multiple conformations of the binding site formed upon ligand binding as a specific structure-based pharmacophore.
55
Monitoring the SARS Epidemic in China: A Time Series Analysis
TL;DR: In this article, three types of time series analysis methods were used in modeling and forecasting the severe acute respiratory syndrome (SARS) epidemic in mainland China, including Box-Jenkins model, autoregressive model with order 1 (AR(1), random walk (ARIMA(0,1,0)) model on the log transformed daily reported SARS cases and the third one was a combination of growth curve fitting and auto-gressive moving average model, ARMA(1,1).
54
Synthesis, biological evaluation and molecular modeling of a novel series of fused 1,2,3-triazoles as potential anti-coronavirus agents
Konstantina Karypidou,Sergio R. Ribone,Mario Alfredo Quevedo,Leentje Persoons,Christophe Pannecouque,Christine Helsen,Frank Claessens,Wim Dehaen +7 more
TL;DR: Synthesis and biological evaluation of a novel library of fused 1,2,3-triazole derivatives showed promising antiviral properties, and in silico studies identified the key molecular interactions between those compounds and the 3-chymotrypsin-like protease, supporting the hypothesis that the protease is the target molecule of the potential antiviral derivatives.
54
Single-dose intranasal administration with mDEF201 (adenovirus vectored mouse interferon-alpha) confers protection from mortality in a lethal SARS-CoV BALB/c mouse model
Yohichi Kumaki,Jane Ennis,Ramtin Rahbar,Jeffrey D. Turner,Miles K. Wandersee,Aaron J. Smith,Kevin W. Bailey,Zachary Vest,Jason R. Madsen,Joseph K.-K. Li,Dale L. Barnard +10 more
TL;DR: The use of an adenovirus vectored mouse IFN alpha gene (mDEF201) as a prophylactic and treatment countermeasure in a SARS-CoV-infected BALB/c mouse model is described and the data suggest that mDEF201 is a new class of antiviral agent further development as treatment for SARS -CoV infections.
54
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IL-13受体α2降低血吸虫病肉芽肿的炎症反应并延长宿主存活时间[英]/Mentink-Kane MM,Cheever AW，Thompson RW，et al//Proc Natl Acad Sci U S A
TL;DR: 曼氏血吸虫感染后，宿主活化CD4^＋Th2细胞Ｌ分泌IL-4、IL-5和 IL-13。
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Identification of a novel coronavirus in patients with severe acute respiratory syndrome.
Christian Drosten,Stephan Günther,Wolfgang Preiser,Sylvie van der Werf,H. R. Brodt,Stephan Becker,Holger F. Rabenau,Marcus Panning,Larissa Kolesnikova,Ron A. M. Fouchier,Annemarie Berger,Ana-Maria Burguière,Jindrich Cinatl,Markus Eickmann,Nicolas Escriou,Klaus Grywna,Stefanie Kramme,Jean-Claude Manuguerra,Stefanie Müller,Volker Rickerts,Martin Stürmer,Simon Vieth,Hans-Dieter Klenk,Albert D. M. E. Osterhaus,Herbert Schmitz,Hans Wilhelm Doerr +25 more
TL;DR: The novel coronavirus might have a role in causing SARS and was detected in a variety of clinical specimens from patients with SARS but not in controls.
A novel coronavirus associated with severe acute respiratory syndrome.
Thomas G. Ksiazek,Dean D. Erdman,Cynthia S. Goldsmith,Zaki,Teresa C. T. Peret,Shannon L. Emery,Suxiang Tong,Urbani C,James A. Comer,Wilina Lim,Pierre E. Rollin,Scott F. Dowell,Ai Ee Ling,Charles D. Humphrey,Wun-Ju Shieh,Jeannette Guarner,Christopher D. Paddock,Paul A. Rota,Barry S. Fields,Joseph L. DeRisi,Jyh-Yuan Yang,Nancy J. Cox,James M. Hughes,James W. LeDuc,William J. Bellini,Larry J. Anderson +25 more
TL;DR: A novel coronavirus is associated with this outbreak of severe acute respiratory syndrome, and the evidence indicates that this virus has an etiologic role in SARS.
Characterization of a novel coronavirus associated with severe acute respiratory syndrome.
Paul A. Rota,M. Steven Oberste,Stephan S. Monroe,W. Allan Nix,Ray Campagnoli,Joseph P. Icenogle,Silvia Peñaranda,Bettina Bankamp,Kaija Maher,Min hsin Chen,Suxiong Tong,Azaibi Tamin,Luis Lowe,Michael Frace,Joseph L. DeRisi,Qi Chen,David Wang,Dean D. Erdman,Teresa C. T. Peret,Cara C. Burns,Thomas G. Ksiazek,Pierre E. Rollin,Anthony Sanchez,Stephanie L. Liffick,Brian P. Holloway,Josef Limor,Karen A. McCaustland,Mellissa Olsen-Rasmussen,Ron A. M. Fouchier,Stephan Günther,Albert Osterhaus,Christian Drosten,Mark A. Pallansch,Larry J. Anderson,William J. Bellini +34 more
TL;DR: Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closelyrelated to any of the previouslycharacterized coronaviruses.
A Major Outbreak of Severe Acute Respiratory Syndrome in Hong Kong
Nelson Lee,David S.C. Hui,Alan Wu,Paul K.S. Chan,Peter Cameron,Gavin M. Joynt,Anil T. Ahuja,Man Yee Yung,Chi-Bon Leung,Ka Fai To,Siu F. Lui,Cheuk-Chun Szeto,S.C.Sydney Chung,Joseph J.Y. Sung +13 more
TL;DR: SARS is a serious respiratory illness that led to significant morbidity and mortality in this cohort of 138 cases of suspected SARS during a hospital outbreak in Hong Kong.
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