Journal Article10.1007/S00330-011-2164-9
Coronary CT angiography: image quality, diagnostic accuracy, and potential for radiation dose reduction using a novel iterative image reconstruction technique—comparison with traditional filtered back projection
Antonio Moscariello,Antonio Moscariello,Richard A.P. Takx,Richard A.P. Takx,U. Joseph Schoepf,Matthias Renker,Peter L. Zwerner,Terrence X. O'Brien,Terrence X. O'Brien,Thomas Allmendinger,Sebastian Vogt,Bernhard Schmidt,Giancarlo Savino,C Fink,C Fink,Lorenzo Bonomo,Thomas Henzler,Thomas Henzler +17 more
306
TL;DR: Iterative reconstruction significantly reduces image noise without loss of diagnostic information and holds the potential for substantial radiation dose reduction from cCTA.
read more
Abstract: To compare image noise, image quality and diagnostic accuracy of coronary CT angiography (cCTA) using a novel iterative reconstruction algorithm versus traditional filtered back projection (FBP) and to estimate the potential for radiation dose savings. Sixty five consecutive patients (48 men; 59.3 ± 7.7 years) prospectively underwent cCTA and coronary catheter angiography (CCA). Full radiation dose data, using all projections, were reconstructed with FBP. To simulate image acquisition at half the radiation dose, 50% of the projections were discarded from the raw data. The resulting half-dose data were reconstructed with sinogram-affirmed iterative reconstruction (SAFIRE). Full-dose FBP and half-dose iterative reconstructions were compared with regard to image noise and image quality, and their respective accuracy for stenosis detection was compared against CCA. Compared with full-dose FBP, half-dose iterative reconstructions showed significantly (p = 0.001 – p = 0.025) lower image noise and slightly higher image quality. Iterative reconstruction improved the accuracy of stenosis detection compared with FBP (per-patient: accuracy 96.9% vs. 93.8%, sensitivity 100% vs. 100%, specificity 94.6% vs. 89.2%, NPV 100% vs. 100%, PPV 93.3% vs. 87.5%). Iterative reconstruction significantly reduces image noise without loss of diagnostic information and holds the potential for substantial radiation dose reduction from cCTA.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Incremental Image Noise Reduction in Coronary CT Angiography Using a Deep Learning-Based Technique with Iterative Reconstruction.
TL;DR: Application of the deep learning technique along with iterative reconstruction can enhance the noise reduction performance with a significant improvement in objective and subjective image qualities of CCTA images.
64
Iterative Image Reconstruction Techniques for CT Coronary Artery Calcium Quantification: Comparison with Traditional Filtered Back Projection in Vitro and in Vivo
Andreas Schindler,Andreas Schindler,Rozemarijn Vliegenthart,Rozemarijn Vliegenthart,U. Joseph Schoepf,P Blanke,P Blanke,Ullrich Ebersberger,Young Jun Cho,Thomas Allmendinger,Sebastian Vogt,Rainer Raupach,C Fink,C Fink,Tobias Saam,Fabian Bamberg,Konstantin Nikolaou,Paul Apfaltrer,Paul Apfaltrer +18 more
TL;DR: In comparison with FBP, iterative reconstruction techniques do not have a profound effect on the reproducible quantification of coronary calcium according to Agatston score and subsequent cardiac risk classification, although risk reclassification may occur in a small subset of subjects.
63
Left atrial volumetry from routine diagnostic work up prior to pulmonary vein ablation is a good predictor of freedom from atrial fibrillation
Christian Sohns,Jan M Sohns,Dirk Vollmann,Lars Lüthje,Leonard Bergau,Marc Dorenkamp,P. A. Zwaka,Gerd Hasenfuß,Joachim Lotz,Markus Zabel +9 more
TL;DR: LA volume assessed by MDCT is a better predictor of AF recurrence after PVA than echocardiograpic LA diameter and can be derived from the pre-procedural imaging data set.
Detection and size measurements of pulmonary nodules in ultra-low-dose CT with iterative reconstruction compared to low dose CT
Xin Sui,Felix G. Meinel,Felix G. Meinel,Wei Song,Xiaoli Xu,Zixing Wang,Yuyan Wang,Zhengyu Jin,Jiuhong Chen,Rozemarijn Vliegenthart,Rozemarijn Vliegenthart,U. Joseph Schoepf +11 more
TL;DR: Ultra-low-dose CT with iterative reconstruction has high sensitivity for lung nodule detection without significant difference in nodule size and volume measurement compared to LDCT.
62
Cardiovascular CT angiography in neonates and children: image quality and potential for radiation dose reduction with iterative image reconstruction techniques.
Francesco Tricarico,Francesco Tricarico,Anthony M. Hlavacek,U. Joseph Schoepf,Ullrich Ebersberger,John W. Nance,John W. Nance,Rozemarijn Vliegenthart,Rozemarijn Vliegenthart,Young Jun Cho,Young Jun Cho,J. Reid Spears,Francesco Secchi,Francesco Secchi,Giancarlo Savino,Riccardo Marano,Stefan O. Schoenberg,Lorenzo Bonomo,Paul Apfaltrer,Paul Apfaltrer +19 more
TL;DR: IR improves image noise, SNR, CNR and subjective IQ compared with FBP in low-radiation-dose paediatric CTA and allows further dose reductions without compromising diagnostic IQ.
60
References
A reporting system on patients evaluated for coronary artery disease. Report of the Ad Hoc Committee for Grading of Coronary Artery Disease, Council on Cardiovascular Surgery, American Heart Association
William G. Austen,JE Edwards,RL Frye,GG Gensini,Vincent L. Gott,LS Griffith,Dwight C. McGoon,ML Murphy,BB Roe +8 more
3.4K
Diagnostic performance of 64-multidetector row coronary computed tomographic angiography for evaluation of coronary artery stenosis in individuals without known coronary artery disease: results from the prospective multicenter ACCURACY (Assessment by Coronary Computed Tomographic Angiography of Individuals Undergoing Invasive Coronary Angiography) trial.
Matthew J. Budoff,David A. Dowe,James G. Jollis,Michael J. Gitter,John Sutherland,Edward Halamert,Markus Scherer,Raye L. Bellinger,Arthur Martin,Robert Benton,Augustin Delago,James K. Min +11 more
TL;DR: In this prospective multicenter trial of chest pain patients without known CAD, 64-multidetector row CCTA possesses high diagnostic accuracy for detection of obstructive coronary stenosis at both thresholds of 50% and 70% stenosis.
2.1K
Diagnostic Accuracy of Noninvasive Coronary Angiography Using 64-Slice Spiral Computed Tomography
TL;DR: Evaluated diagnostic accuracy of multislice computed tomography (MSCT) coronary angiography using a new 64-slice scanner indicates high quantitative and qualitative diagnostic accuracy in comparison to QCA in a broad spectrum of patients.
1.6K
Estimating Risk of Cancer Associated With Radiation Exposure From 64-Slice Computed Tomography Coronary Angiography
TL;DR: Estimates derived from simulation models suggest that use of 64-slice CTCA is associated with a nonnegligible LAR of cancer, which varies markedly and is considerably greater for women, younger patients, and for combined cardiac and aortic scans.
1.5K
First performance evaluation of a dual-source CT (DSCT) system.
Thomas Flohr,Cynthia H. McCollough,Herbert Bruder,Martin Petersilka,Klaus Gruber,Christoph Süß,Michael Grasruck,Karl Stierstorfer,Bernhard Krauss,Rainer Raupach,Andrew N. Primak,Axel Küttner,S. Achenbach,Christoph R. Becker,Andreas F. Kopp,Bernd Ohnesorge +15 more
TL;DR: First clinical experience shows a considerably increased robustness for the imaging of patients with high heart rates, and the automatic separation of bones and iodine-filled vessels is demonstrated as a potential application of the dual-energy acquisition mode.