Journal Article10.1016/J.NEURO.2013.12.001
Copper toxicity induced hepatocerebral and neurodegenerative diseases: an urgent need for prognostic biomarkers.
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TL;DR: Proteomics study of cerebrospinal fluid, due to its high specificity and sensitivity represents an alternative approach to study early peripheral Cu neurotoxicity biomarker/s in experimental animals, and network biology, transcriptomics in conjunction with novel in vivo Cu imaging techniques allow us to explore other potential candidates and propose new targets to be studied for chronic Cu neurot toxicity biomarkers, and for possible therapeutic interventions.
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Abstract: Copper (Cu) has been the subject of intensive research over several decades as numerous evidence robustly support the involvement of excess Cu induced neurotoxicity in hepatocerebral (Wilson's disease) and neurodegenerative disorders (especially Alzheimer's disease and Parkinson's disease); notwithstanding, the ideal Cu neurotoxicity biomarker/s for early prognosis remains elusive. Non-ceruloplasmin bound Cu is a biological marker of Wilson's disease and recent studies have shown that its levels are also increased in Alzheimer's disease. Copper chaperone for superoxide dismutase seems to be the other most promising biomarker of Cu toxicity (subject to its validation). Serum/plasma Cu, urine Cu and ceruloplasmin concentrations, most widely used laboratory indicators to diagnose Wilson's disease, are not specific for Cu excess milieu as these are also influenced by age, sex, inflammation and hormonal status. High inter-individual variability, nonexistence of standardized assays and non-specificity limit the use of other cuproenzymes as biomarkers of Cu neurotoxicity. The majority of Cu neurotoxicity biomarker research has focused in plasma/serum where other factors including inflammation, oxidative stress, dietary and environmental factors influence the Cu condition being studied. Proteomics study of cerebrospinal fluid, due to its high specificity and sensitivity represents an alternative approach to study early peripheral Cu neurotoxicity biomarker/s in experimental animals. In addition, network biology, transcriptomics in conjunction with novel in vivo Cu imaging techniques allow us to explore other potential candidates and propose new targets to be studied for chronic Cu neurotoxicity biomarker/s, and for possible therapeutic interventions.
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Citations
Copper toxicology, oxidative stress and inflammation using zebrafish as experimental model
TL;DR: An overview of copper metabolism in health and disease and its effects on oxidative stress and inflammation responses in zebrafish models is provided, and copper‐induced inflammation is highlighted owing to its potential to easily mimic pro‐oxidative and pro‐inflammatory features that combined with zebra fish genetic tractability could help further in the understanding of Copper metabolism, inflammatory responses and related diseases.
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Biochemical Markers for the Diagnosis and Monitoring of Wilson Disease.
Isabelle Mohr,Karl Heinz Weiss +1 more
- 01 May 2019
TL;DR: The following review focuses especially on biochemical markers and how they can be utilised in diagnosis and drug monitoring.
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CDKN2A-mediated molecular subtypes characterize the hallmarks of tumor microenvironment and guide precision medicine in triple-negative breast cancer
TL;DR: The potential of CDKN2A as a pioneering prognostic predictor for T NBC is indicated and a rationale of immunotherapy for TNBC is provided, and fresh perspectives and orientations for cancer treatment via inducing ferroptosis and cuproPTosis to develop novel anti-cancer treatment strategies are offered.
Molecular docking, a tool to determine interaction of CuO and TiO 2 nanoparticles with human serum albumin.
Sandesh Chibber,Irshad Ahmad +1 more
TL;DR: The structural information that derives from this study for CuO and TiO2 nanoparticles may be useful in terms of both high and low-affinity binding sites when designing these nanoparticles based drugs delivery system.
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A dual-responsive anthrapyridone-triazole-based probe for selective detection of Ni2+ and Cu2+: A mimetic system for molecular logic gates based on color change
TL;DR: A newly synthesized anthrapyridone-based probe (probe 1) with a pyrene-1-triazole unit as a pendant exhibited selective and sensitive detection of Cu2+ and Ni2+ among various metal ions.
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References
EASL Clinical Practice Guidelines: Wilson's disease
Peter Ferenci,Anna Członkowska,Wolfgang Stremmel,Roderick H. J. Houwen,William Rosenberg,Michael L. Schilsky,P Jansen,Darius Moradpour,J D Gitlin +8 more
- 01 Mar 2012
TL;DR: There is not a single randomized controlled trial conducted in Wilson's disease which has an optimal design so it is impossible to assign a high or even a moderate quality of evidence to any of the questions dealt with in these guidelines.
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Measurement of Ceruloplasmin from Its Oxidase Activity in Serum by Use of o-Dianisidine Dihydrochloride
TL;DR: A new method for determination of serum ceruloplasmin from its oxidase activity is developed, in which o -dianisidine dihydrochloride is used as substrate, and forms a stable product that is measured at 540 nm.
626
ATP7A-related copper transport diseases-emerging concepts and future trends
TL;DR: It is indicated that ATP7A has a crucial but previously unappreciated role in motor neuron maintenance, and that the mechanism underlying ATP 7A-related distal motor neuropathy is distinct from Menkes disease and OHS pathophysiology.
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Copper and iron disorders of the brain.
TL;DR: This review focuses on the inherited disorders in humans that directly affect copper or iron homeostasis in the brain and the molecular genetic basis of these rare disorders has provided insight into the mechanisms of copper and iron acquisition, trafficking, storage, and excretion in thebrain.
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An improved colorimetric enzymatic assay of ceruloplasmin
TL;DR: An improved colorimetric enzymatic assay of ceruloplasmin is described in detail, providing an optimal combination of technical simplicity with precision and reliability of results.
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