Copper nanoparticles and copper ions promote horizontal transfer of plasmid-mediated multi-antibiotic resistance genes across bacterial genera.
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TL;DR: In conclusion, this study reports both CuO NPs and copper ions (Cu2+) could stimulate the conjugative transfer of multiple-drug resistance genes and suggests the over-production of reactive oxygen species played a crucial role in promoting conjugatives transfer.
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About: This article is published in Environment International. The article was published on 31 May 2019. and is currently open access.
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Citations
Understanding human health risks caused by antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARG) in water environments: Current knowledge and questions to be answered
TL;DR: This review summarizes the current knowledge regarding the ARB and ARGs in aquatic environments and highlights the challenging questions remaining to be answered to better forecast the health risks caused by ARB/ARGs in water environments.
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Anh Q. Nguyen,Hang P. Vu,Luong N. Nguyen,Qilin Wang,Steven P. Djordjevic,Erica Donner,Huabing Yin,Long D. Nghiem +7 more
TL;DR: In this paper, the authors provide a research roadmap to address existing challenges in AMR control via wastewater treatment, including inconsistencies in ARG reporting units, lack of ARG/ARB monitoring surrogates, and lack of a standardised protocol for determining ARG removal via wastewater treatments.
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Antibacterial Nanomaterials: Mechanisms, Impacts on Antimicrobial Resistance and Design Principles.
Maomao Xie,Mengxu Gao,Yang Yun,Martin Malmsten,Vincent M. Rotello,Radek Zboril,Omid Akhavan,A. N. Kraskouski,John Amalraj,Xiaoming Cai,Jianmei Lu,Huizhen Zheng,Rui-Qing Li +12 more
TL;DR: In this paper , the authors compared the killing mechanisms and structure-activity relationships of antibiotics and antimicrobial nanomaterials, and then focused on nano-microbe interactions to elucidate the impacts of molecular initiating events on AMR evolution.
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Intracellular versus extracellular antibiotic resistance genes in the environment: Prevalence, horizontal transfer, and mitigation strategies.
Ali Zarei-Baygi,Adam L. Smith +1 more
TL;DR: Evaluation of prevalence/persistence and horizontal transfer of iARGs and extracellular ARGs (eARGs) in different environments, and advanced mitigation strategies in wastewater treatment plants (WWTPs) for preventing the spread of antibiotic resistance in the environment are explored.
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Effects of emerging pollutants on the occurrence and transfer of antibiotic resistance genes: A review
TL;DR: A comprehensive review of the effects and intrinsic mechanisms of EPs, including microplastics, engineered nanomaterials, disinfection byproducts, pharmaceuticals, and personal care products, on the occurrence and dissemination of ARGs is presented in this paper.
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References
Role of porin proteins OmpF and OmpC in the permeation of beta-lactams.
A Jaffe,Y A Chabbert,O Semonin +2 more
TL;DR: Mutants of Escherichia coli K-12 lacking major outer membrane proteins were obtained by selecting for resistance to the beta-lactam cefoxitin by finding mutants in ompB, a regulatory locus for proteins OmpF and OmpC.
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