Journal Article10.1002/ANIE.201712512
Convergence for Translation: Drug-Delivery Research in Multidisciplinary Teams.
10
TL;DR: Examples of successful sustained delivery systems for antimalarials and antiretrovirals, as well as to the gastrointestinal tract are discussed.
read more
Abstract: The void between drug discovery and successful translation to humans is vast. In order to develop effective solutions, convergence of a multidisciplinary team with a range of expertise is required. In this Essay, examples of successful sustained delivery systems for antimalarials and antiretrovirals, as well as to the gastrointestinal tract are discussed.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Ingestible electronics for diagnostics and therapy
Christoph Steiger,Christoph Steiger,Abramson Alex G,Phillip Nadeau,Phillip Nadeau,Anantha P. Chandrakasan,Robert Langer,Giovanni Traverso,Giovanni Traverso +8 more
TL;DR: Clinical applications of ingestible electronic devices are discussed and materials and sensor technologies, drug delivery applications and major challenges and opportunities for clinical translation, such as safety, powering and communication are investigated.
215
Formulation strategies to improve the efficacy of intestinal permeation enhancers.
Sam Maher,David J. Brayden +1 more
TL;DR: The use of chemical permeation enhancers (PEs) is the most widely tested approach to improve oral absorption of low permeability active agents, as represented by peptides as mentioned in this paper.
62
Electrobiofabrication: electrically based fabrication with biologically derived materials.
Jinyang Li,Si Wu,Eunkyoung Kim,Kun Yan,Huan Liu,Changsheng Liu,Hua Dong,Xue Qu,Xiaowen Shi,Jana Shen,William E. Bentley,Gregory F. Payne +11 more
TL;DR: Electrobiofabrication will emerge as an important platform technology for organizing soft matter into dynamic material systems that mimic biology's complexity of structure and versatility of function.
Physical methods for enhancing drug absorption from the gastrointestinal tract.
TL;DR: A plethora of formulation strategies ranging from permeation enhancers, nanosized carriers, and chemical modifications of the drug's structure has been investigated to increase the oral absorption of these macromolecular compounds.
32
Transmucosal Absorption Enhancers in the Drug Delivery Field.
TL;DR: This editorial is an introduction to the special issue entitled Transmucosal Absorption Enhancers in the Drug Delivery Field, and the guest editors outline the scope of the issue, reflect on the results and the conclusions of the 19 articles published in the issue and provide an outlook on the use of permeation enhancer in the drug delivery field.
25
References
Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies
Siew C. Ng,Hai Yun Shi,Hai Yun Shi,Nima Hamidi,Fox E. Underwood,Whitney Tang,Eric I Benchimol,Eric I Benchimol,Remo Panaccione,Subrata Ghosh,Justin C.Y. Wu,Francis K.L. Chan,Joseph J.Y. Sung,Gilaad G. Kaplan +13 more
TL;DR: The changing incidence and prevalence of inflammatory bowel disease around the world has become a global disease with accelerating incidence in newly industrialised countries whose societies have become more westernised and burden remains high as prevalence surpasses 0·3%.
4.7K
Transdermal drug delivery
Mark R. Prausnitz,Robert Langer +1 more
TL;DR: Third-generation delivery systems target their effects to skin's barrier layer of stratum corneum using microneedles, thermal ablation, microdermabrasion, electroporation and cavitational ultrasound for delivery of macromolecules and vaccines.
Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies
TL;DR: Recent advances in formulation and delivery strategies, such as the use of microsphere-based controlled-release technologies, protein modification methods that make use of polyethylene glycol and other polymers, and genetic manipulation of biopharmaceutical drugs are highlighted and discussed.
1.5K
Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers.
TL;DR: The protective barrier properties of mucus secretions, how mucus affects the fate of orally administered nanoparticles, and recent developments in nanoparticles engineered to penetrate the mucus barrier are addressed.
1.4K
Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals
TL;DR: In addition to metabolic differences, the anatomical, physiological, and biochemical differences in the gastrointestinal (G.I.) tract of the human and common laboratory animals can cause significant variation in drug absorption from the oral route.
1.3K
Related Papers (5)
Ram I. Mahato,Ajit S. Narang +1 more
- 22 Nov 2017
Marc B. Brown,Adrian C. Williams +1 more
- 01 Mar 2019