Journal Article10.1002/ANIE.201403249
Control of Three-Dimensional Cell Adhesion by the Chirality of Nanofibers in Hydrogels
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TL;DR: It was found that left-handed helical nanofibers can increase cell adhesion and proliferation, whereas right-handed nan ofibers have the opposite effect.
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Abstract: In the three-dimensional (3D) extracellular matrix (ECM), the influence of nanofiber chirality on cell behavior is very important; the helical nanofibrous structure is closely related to the relevant biological events. Herein, we describe the use of the two enantiomers of a 1,4-benzenedicarboxamide phenylalanine derivative as supramolecular gelators to investigate the influence of the chirality of nanofibers on cell adhesion and proliferation in three dimensions. It was found that left-handed helical nanofibers can increase cell adhesion and proliferation, whereas right-handed nanofibers have the opposite effect. These effects are ascribed to the mediation of the stereospecific interaction between chiral nanofibers and fibronectin. The results stress the crucial role of the chirality of nanofibers on cell-adhesion and cell-proliferation behavior in 3D environments.
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Citations
Controlling 1D Nanostructures and Handedness by Polar Residue Chirality of Amphiphilic Peptides.
Hai Xu,Kai Qi,Cheng Zong,Jing Deng,Xuzhi Hu,Xiaoyue Ma,Dong Wang,Muhan Wang,Jun Zhang,Stephen M King,Sarah E Rogers,Jian Ren Lu,Jun Yang,Jiqian Wang +13 more
TL;DR: This work lays a useful foundation for the fabrication of diverse peptide nanostructures by manipulating the chirality of specific residues and provides a framework for predicting the supramolecular structures and handedness of peptide assemblies from single molecule conformations.
Chiral Induction in a Self‐Assembled Pd4 Coordination Cage with Chiral Guests
Raghunath Singha,Pulakesh Maity,Dipak Samanta +2 more
TL;DR: Self-assembled chiral cage formation and enantioselective complexation through chiral guest recognition.
Trends in design of C2-symmetric supramolecular chiral gelators
TL;DR: A review of the current state of research on functional nano-scale systems, the design, synthesis, and applications of self-assembled C2-symmetric supramolecular chiral gelators "engineered" to carry out precise functions is presented in this article.
Multi-responsive supramolecular hydrogels for drug delivery
TL;DR: A versatile method is reported to prepare multi-responsive supramolecular hydrogels for drug delivery application and it is shown that this method can be used for multiple drug delivery applications.
Additional file 1 of Chiral MoS2@BC fibrous membranes selectively promote peripheral nerve regeneration
Li Mengru,Li Xiao,Yan Hede,Wang Xiang-yang,He Jin,Zhou Chao,Ouyang Yuanming +6 more
- 15 Aug 2024
Abstract: Additional file 1: Fig. S1. Mechanical properties of BC, D-CMS, L-CMS, Ach-MS and R-CMS materials. A Tensile strength of BC, D-CMS, L-CMS, Ach-MS and R-CMS materials. B Stress-strain curves for BC, D-CMS, L-CMS, Ach-MS and R-CMS materials. C Stress profiles of BC, D-CMS, L-CMS, Ach-MS and R-CMS materials with time. Fig. S2. Immunofluorescence of SCs on BC, D-CMS, L-CMS, Ach-MS and R-CMS scaffolds. A CJun immunofluorescence. B Relative levels of CJun (n = 3). Table S1. Experimental reagents. Table S2. Experimental Instruments. Table S3. Mechanisms of different types of nerve conduits promoting peripheral nerve regeneration.
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