Control of brown and beige fat development
Wenshan Wang,Patrick Seale +1 more
628
TL;DR: F Fate-mapping analyses have identified progenitor populations that give rise to brown and beige fat cells, and have revealed unanticipated cell-lineage relationships between vascular smooth muscle cells and bege adipocytes, and between skeletal Muscle cells and brown fat.
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Abstract: Brown and beige adipocytes expend chemical energy to produce heat and are therefore important in regulating body temperature and body weight. Brown adipocytes develop in discrete and relatively homogenous depots of brown adipose tissue, whereas beige adipocytes are induced to develop in white adipose tissue in response to certain stimuli - notably, exposure to cold. Fate-mapping analyses have identified progenitor populations that give rise to brown and beige fat cells, and have revealed unanticipated cell-lineage relationships between vascular smooth muscle cells and beige adipocytes, and between skeletal muscle cells and brown fat. In addition, non-adipocyte cells in adipose tissue, including neurons, blood vessel-associated cells and immune cells, have crucial roles in regulating the differentiation and function of brown and beige fat.
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TL;DR: In this article, the role of UCP in the regulation of body mass was determined by targeted inactivation of the gene encoding it, and it was found that UCP-deficient mice consume less oxygen after treatment with a β3-adrenergic-receptor agonist and are sensitive to cold, indicating that their thermo-regulation is defective.
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Barbara Cannon,Jan Nedergaard +1 more
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Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis
Davina Wu,Ari B. Molofsky,Hong-Erh Liang,Roberto R. Ricardo-Gonzalez,Hani A. Jouihan,Jennifer K. Bando,Ajay Chawla,Richard M. Locksley +7 more
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UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality
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Natasa Petrovic,Tomas B. Walden,Irina G. Shabalina,James A. Timmons,Barbara Cannon,Barbara Cannon,Jan Nedergaard +6 more
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