Journal Article10.1038/s41586-023-06268-1
Continuous synthesis of E. coli genome sections and Mb-scale human DNA assembly
Jérôme F Zürcher,Askar A. Kleefeldt,Louise F. H. Funke,Julius Fredens,Simona Grazioli,Kim Liu,Martin Spinck,Gianluca Petris,Pierre Murat,Julian E. Sale,Jason W. Chin +10 more
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About: This article is published in Visual education. The article was published on 28 Jun 2023. The article focuses on the topics: Medicine & Genome.
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Citations
Cracking the Code: Reprogramming the Genetic Script in Prokaryotes and Eukaryotes to Harness the Power of Noncanonical Amino Acids
Cosimo Jann,Sabrina Giofrè,Rajanya Bhattacharjee,Edward A. Lemke +3 more
TL;DR: Researchers review genetic code expansion methodologies in prokaryotes (E. coli) and eukaryotes (mammalian cells), highlighting challenges and promising developments in harnessing noncanonical amino acids for biotechnology, materials science, and medicine applications.
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The design and engineering of synthetic genomes
Joshua S. James,Junbiao Dai,Wei Leong Chew,Yizhi Cai +3 more
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Genetic Code Expansion History and Modern Innovations
Alan Costello,Alexander A. Peterson,Pei‐Hsin Chen,Rustam Bagirzadeh,David L. Lanster,Ahmed H. Badran +5 more
TL;DR: This review summarizes the history and modern innovations of genetic code expansion, highlighting advances in extending the amino acid repertoire to include noncanonical building blocks in a single protein, with a focus on recent developments and future directions.
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Efficient Genetic Code Expansion Without Host Genome Modifications
Alan Costello,Alexander A. Peterson,David L. Lanster,Zhiyi Li,Gavriela D. Carver,Ahmed H. Badran +5 more
TL;DR: Efficient genetic code expansion without host genome modifications using codon compression strategy.
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Efficient genetic code expansion without host genome modifications
Alan Costello,Alexander A. Peterson,David L. Lanster,Z Li,Gavriela D. Carver,Ahmed H. Badran +5 more
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TL;DR: The results of an international collaboration to produce and make freely available a draft sequence of the human genome are reported and an initial analysis is presented, describing some of the insights that can be gleaned from the sequence.
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