Consanguinity among the Saudi Arabian population.
Mohsen A. F. El-Hazmi,Abdul Rahman Al-Swailem,Arjumand S. Warsy,A. M. Al-Swailem,R. Sulaimani,Abdul Aziz Al-Meshari +5 more
TL;DR: The overall rate of consanguinity shows that 57.7% of the families screened were consanguineous in Saudi Arabia, which place Saudi Arabia among the countries of the world with a high rate of Consanguinity.
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Abstract: This study was conducted on 3212 Saudi families to investigate the prevalence of consanguineous marriages. The families were interviewed and the information on the relationship between the husband and wife was obtained. The overall rate of consanguinity shows that 57.7% of the families screened were consanguineous. The most frequent were first cousin marriages (28.4%) followed by distant relative marriages (15.2%) and second cousin marriages (14.6%). The families were grouped according to the province of their origin and the consanguinity rates were calculated accordingly. There were slight differences in the consanguinity rates in the five provinces, which ranged from 52.1% to 67.7%. In each province first cousin marriages were the most frequently encountered pattern, ranging from 17.9% to 40.9%. The inbreeding coefficient (F) was calculated for each province and ranged from 0.020 to 0.030. Within each province, there were several significant differences among the populations in the different areas. The highest rate of consanguinity was 80.6% in Samtah and the lowest rate was around 34% in Abha in the South Western province. These results place Saudi Arabia among the countries of the world with a high rate of consanguinity. The possible consequences of increased consanguinity are presented and discussed.
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Consanguinity and reproductive health among Arabs.
Ghazi O. Tadmouri,Pratibha Nair,Tasneem Obeid,Mahmoud Taleb Al Ali,Najib Al Khaja,Hanan A Hamamy +5 more
TL;DR: Data on genetic disorders in Arab populations as extracted from the Catalogue of Transmission Genetics in Arabs (CTGA) database indicate a relative abundance of recessive disorders in the region that is clearly associated with the practice of consanguinity.
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Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC).
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Six-year outcome of the national premarital screening and genetic counseling program for sickle cell disease and β-thalassemia in Saudi Arabia
TL;DR: Six years of premarital screening in Saudi Arabia markedly reduced the number of at-risk marriages, which may considerably reduce the genetic disease burden in Saudi Saudi Arabia in the next decades.
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Consanguineous marriage: Current global incidence and its relevance to demographic research
Alan H. Bittles
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Haemoglobinopathies, Thalassaemias and Enzymopathies in Saudi Arabia
TL;DR: The sickle cell gene, α- and β-thalassaemia and glucose-6-phosphate dehydrogenase deficiency genes have been encountered in almost all regions of Saudi Arabia at a variable frequency.
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