Cone photoreceptors in laminated retinal transplants.
3
TL;DR: Full-thickness embryonic rabbit retinal transplants develop into laminated retinas with well-developed photoreceptor outer segment and the ratio between the two cone types is the same as in the normal adult rabbit retina.
read more
Abstract: PURPOSE: To investigate the contents of green- and blue-sensitive cone photoreceptors in laminated rabbit retinal transplants.METHODS: Eleven rabbits each received a sheet of embryonic neuroretina into the subretinal space in one eye. Vitrectomy was used in the procedure and properly polarized flat transplants were placed on the host pigment epithelium. After 17-309 days the transplants were examined immunohistochemically with specific antibodies against COS-1 (green-sensitive cones) and OS-2 (blue-sensitive cones).RESULTS: All grafts displayed normal lamination with well developed photoreceptor outer segments apposed to the host retinal pigment epithelium. Occasionally, rosettes were found at the transplant edges. Both COS-1 positive and OS-2 positive cones were detected. In the laminated part of the grafts, COS-1 positive cones were more numerous than OS-2 positive ones. In the rosetted parts of the transplants the relationship between the cones was reversed.CONCLUSION: Full-thickness embryonic rabbit retinal transplants develop into laminated retinas with well-developed photoreceptor outer segment. Both green- and blue-sensitive cone photoreceptors are present and the ratio between the two cone types is the same as in the normal adult rabbit retina. (Less)
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Outer retinal tubulation: a novel optical coherence tomography finding
Sandrine A. Zweifel,Michael Engelbert,Ketan Laud,Ron Margolis,Richard F. Spaide,K. Bailey Freund +5 more
TL;DR: Degenerating photoreceptors may become arranged in a circular or ovoid fashion during a process proposed to term outer retinal tubulation, apparently common in advanced diseases affecting the outer retina and retinal pigment epithelium.
309
•Dissertation
Interactions between neural retina,retinal epithelium and choroid
Lena Ivert
- 25 May 2006
TL;DR: This project investigates how surgical manipulation of the retinal epithelium layer influences the neural retina, the choroid and the epithelial layer itself and offers insights into how the methodology for surgical repair of these structures such as gene therapy and/or transplantation can be made more effective.
4
Bone marrow-derived stem cells can differentiate into retinal cells in injured rat retina.
Minoru Tomita,Yasushi Adachi,H. Yamada,Kanji Takahashi,Katsuji Kiuchi,Haruki Oyaizu,Kazuya Ikebukuro,Hiroyuki Kaneda,Miyo Matsumura,Susumu Ikehara +9 more
TL;DR: The results raise the possibility that stem cell‐enriched BMCs have the ability to differentiate into retinal neural cells, and that the injection of stemcell‐en enriched BMCs into the retina would help repair damaged retinal cells.
References
Newborn rat retinal cells transplanted into a retinal lesion site in adult host eyes.
James E. Turner,Jerry R. Blair +1 more
TL;DR: For the first time a method utilizing immature retinal grafts to fill and/or bridge the wound area of the lesioned adult mammalian retina is reported, demonstrating the utility of using this model for the study of numerous retinal developmental phenomena.
118
•Journal Article
Complementary cone fields of the rabbit retina.
TL;DR: In addition to the visual streak primarily abundant in green cones, there is a specialized area of the rabbit retina that is densely and exclusively populated with blue cones that is designated as the blue streak of the Rabbit retina.
87
Regional topography of rod and immunocytochemically characterized "blue" and "green" cone photoreceptors in rabbit retina.
TL;DR: It is found that densities of photoreceptors vary systematically, depending upon the size of the eye and age of the animal, and questions are raised about the identities of the visual pigment epitopes, the possibility of double labeling, and therefore the possible of dual expression of pigments in single cones.
85