Journal Article10.1056/NEJM198706113162405
Concurrent morning increase in platelet aggregability and the risk of myocardial infarction and sudden cardiac death.
Geoffrey H. Tofler,Damian Brezinski,Andrew I. Schafer,Charles A. Czeisler,John D. Rutherford,Stefan N. Willich,Ray E. Gleason,Gordon H. Williams,James E. Muller +8 more
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TL;DR: The period from 6 to 9 a.m. was the only interval in the 24-hour period during which platelet aggregability increased significantly, and in vitro platelet responsiveness to either adenosine diphosphate or epinephrine was lower.
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Abstract: We have previously reported that the frequencies of myocardial infarction and of sudden cardiac death are highest during the period from 6 a.m. to noon. Since platelet aggregation may have a role in triggering these disorders, we measured platelet activity at 3-hour intervals for 24 hours in 15 healthy men. In vitro platelet responsiveness to either adenosine diphosphate (ADP) or epinephrine was lower at 6 a.m. (before the subjects arose) than at 9 a.m. (60 minutes after they arose). The lowest concentration of these agents required to produce biphasic platelet aggregation decreased (i.e., aggregability increased) from a mean ±SEM of 4.7±0.6 to 3.7±0.6 μM (P<0.01) for ADP and from 3.7±0.8 to 1.8±0.5 μM (P<0.01) for epinephrine. The period from 6 to 9 a.m. was the only interval in the 24-hour period during which platelet aggregability increased significantly. We subsequently studied 10 subjects on alternate mornings after they arose at the normal time and after delayed arising. The morning increas...
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Citations
Chronobiology of Circulating Blood Cells and Platelets
E. Haus
- 01 Jan 1992
TL;DR: The great variability in the number of circulating formed elements in the peripheral blood has been noted since techniques for counting these structures became available during the second half of the last century, and it became apparent that some of these periodic variations are highly reproducible and predictable in their timing and, in some instances, are large enough to be of clinical interest.
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Influence of beta-adrenergic blockade defined by time series analysis on circadian variation of heart rate and ambulatory myocardial ischemia.
Charles R. Lambert,Charles R. Lambert,Kevin M. Coy,Kevin M. Coy,Greg A. Imperi,Greg A. Imperi,Carl J. Pepine,Carl J. Pepine +7 more
TL;DR: Time series analysis suggests close coupling between the variation in heart rate and ambulatory ischemia in patients with severe coronary artery disease and beta 1-adrenergic blockade.
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Acute and chronic psychological stress in coronary disease
TL;DR: It is suggested that, taken as a whole, evidence for a psychological and social impact on CAD morbidity and mortality is convincing.
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Supine rest reduces platelet activation and aggregation
TL;DR: It is shown that a person's ordinary daily routine contributes to platelet activation and aggregation, and that these can be reduced by supine rest, which suggests a mechanism by which bed rest in a calm environment may contribute, however slightly, to the management of acute coronary syndromes.
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Gender differences in triggering of acute myocardial infarction
TL;DR: The frequencies of potential triggers of acute myocardial infarction differ between men and women, and there is a possibility that anti-ischemic drugs protect against trigger-related infarctions.
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