Concise Review: MSC Adhesion Cascade—Insights into Homing and Transendothelial Migration
Franziska Nitzsche,Claudia Müller,Barbara Lukomska,Jukka Jolkkonen,Alexander Deten,Johannes Boltze,Johannes Boltze +6 more
TL;DR: In this paper, a detailed overview over the current knowledge of MSC transendothelial migration is provided, using the leukocyte extravasation process as a role model to build a comprehensive concept of mesenchymal stem cell egress mechanisms from the blood stream and identified relevant similarities as well as important differences between the different mechanisms.
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Abstract: Mesenchymal stem cells (MSCs) are promising candidates for adult cell therapies in regenerative medicine To fully exert their potential, efficient homing and migration toward lesion sites play an important role Local transplantation deposits MSC in spatial proximity to the lesion, but often requires invasive procedures Systemic administration routes are favored, but require the targeted extravasation of the circulating MSC at the site of injury Transplanted MSC can indeed leave the blood flow and transmigrate through the endothelial barrier, and reach the lesion site However, the underlying processes are not completely dissolved yet Recent in vitro and in vivo research identified some key molecules scattered light on the extravasation mechanism This review provides a detailed overview over the current knowledge of MSC transendothelial migration We use the leukocyte extravasation process as a role model to build a comprehensive concept of MSC egress mechanisms from the blood stream and identified relevant similarities as well as important differences between the extravasation mechanisms Stem Cells 2017;35:1446-1460
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References
Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
Massimo Dominici,K. Le Blanc,Ingo Mueller,I. Slaper-Cortenbach,Frank C. Marini,Diane S. Krause,Robert J. Deans,Armand Keating,Darwin J. Prockop,Edwin M. Horwitz +9 more
TL;DR: The Mesenchymal and Tissue Stem Cell Committee of the International Society for Cellular Therapy proposes minimal criteria to define human MSC, believing this minimal set of standard criteria will foster a more uniform characterization of MSC and facilitate the exchange of data among investigators.
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Getting to the site of inflammation: the leukocyte adhesion cascade updated
TL;DR: This Review focuses on new aspects of one of the central paradigms of inflammation and immunity — the leukocyte adhesion cascade.
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Mesenchymal stem cells reside in virtually all post-natal organs and tissues
TL;DR: The results suggest that the distribution of MSCs throughout the post-natal organism is related to their existence in a perivascular niche, which has implications for understanding MSC biology, and for clinical and pharmacological purposes.