Concise Review: MSC Adhesion Cascade—Insights into Homing and Transendothelial Migration
Franziska Nitzsche,Claudia Müller,Barbara Lukomska,Jukka Jolkkonen,Alexander Deten,Johannes Boltze,Johannes Boltze +6 more
TL;DR: In this paper, a detailed overview over the current knowledge of MSC transendothelial migration is provided, using the leukocyte extravasation process as a role model to build a comprehensive concept of mesenchymal stem cell egress mechanisms from the blood stream and identified relevant similarities as well as important differences between the different mechanisms.
read more
Abstract: Mesenchymal stem cells (MSCs) are promising candidates for adult cell therapies in regenerative medicine To fully exert their potential, efficient homing and migration toward lesion sites play an important role Local transplantation deposits MSC in spatial proximity to the lesion, but often requires invasive procedures Systemic administration routes are favored, but require the targeted extravasation of the circulating MSC at the site of injury Transplanted MSC can indeed leave the blood flow and transmigrate through the endothelial barrier, and reach the lesion site However, the underlying processes are not completely dissolved yet Recent in vitro and in vivo research identified some key molecules scattered light on the extravasation mechanism This review provides a detailed overview over the current knowledge of MSC transendothelial migration We use the leukocyte extravasation process as a role model to build a comprehensive concept of MSC egress mechanisms from the blood stream and identified relevant similarities as well as important differences between the extravasation mechanisms Stem Cells 2017;35:1446-1460
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Multiple Dimensions of using Mesenchymal Stem Cells for Treating Liver Diseases: From Bench to Beside.
Lijun Chen,Ning Zhang,Yuqi Huang,Qi Zhang,Yangxin Fang,Jiamin Fu,Yin Yuan,Lu Chen,Xin Chen,Zhenyu Xu,Yifei Li,Hiromi Izawa,Charlie Xiang +12 more
TL;DR: MSCs have great potential in the treatment of liver diseases based on their multi-faceted characteristics, and more accurate mechanisms and novel therapeutic strategies stemming from MSCs will facilitate clinical practice.
8
Pharmacokinetic characteristics of mesenchymal stem cells in translational challenges
Yunlong Shan,Mengying Zhang,Enxiang Tao,Jing Wang,Ning Wei,Yi Lü,Qing Liu,Kun Hao,Fang Zhou,Guangji Wang +9 more
TL;DR: This review examines the pharmacokinetic characteristics of mesenchymal stem cells, their therapeutic effects, and challenges in commercial applications, highlighting the need for advanced imaging and tracking technologies to improve MSC clinical efficacy and market introduction.
8
Bioactive borate glass triggers phenotypic changes in adipose stem cells.
Nathan J Thyparambil,Lisa C Gutgesell,Bradley A Bromet,Lauren E Flowers,Samantha Greaney,Delbert E. Day,Julie A. Semon +6 more
TL;DR: Results show that B3 alters the protein secretion of ASCs, which has been shown to have multiple roles in wound repair.
8
Biophysical cues to improve the immunomodulatory capacity of mesenchymal stem cells: The progress and mechanisms.
Xiangpan Li,Yanan Kong,Lintao Bi,Lisha Li +3 more
- 07 Apr 2023
TL;DR: A review of the main ways in which mesenchymal stem cells exert their immunomodulatory ability, and summarize recent advances in mechanical preconditioning of MSCs to enhance immunOModulatory capacity and related mechanical signal sensing and transduction mechanisms is presented in this paper .
8
Transplanted hair follicle mesenchymal stem cells alleviated small intestinal ischemia–reperfusion injury via intrinsic and paracrine mechanisms in a rat model
Yang Gao,Haoyuan Chen,Xueyu Cang,Hongliang Chen,Yuzhu Di,Jihan Qi,Huimin Cai,Kunpeng Luo,Shizhu Jin +8 more
TL;DR: Hair follicle MSCs are beneficial to alleviate small intestinal IR injury through intrinsic homing to the small intestine and by differentiating into ISCs, via a paracrine mechanism to promote angiogenesis, reduce apoptosis, regulate the oxidative stress response, and protect intestinal mucosal function potentially.
References
Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
Massimo Dominici,K. Le Blanc,Ingo Mueller,I. Slaper-Cortenbach,Frank C. Marini,Diane S. Krause,Robert J. Deans,Armand Keating,Darwin J. Prockop,Edwin M. Horwitz +9 more
TL;DR: The Mesenchymal and Tissue Stem Cell Committee of the International Society for Cellular Therapy proposes minimal criteria to define human MSC, believing this minimal set of standard criteria will foster a more uniform characterization of MSC and facilitate the exchange of data among investigators.
17.5K
Getting to the site of inflammation: the leukocyte adhesion cascade updated
TL;DR: This Review focuses on new aspects of one of the central paradigms of inflammation and immunity — the leukocyte adhesion cascade.
4.4K
Mesenchymal stem cells reside in virtually all post-natal organs and tissues
TL;DR: The results suggest that the distribution of MSCs throughout the post-natal organism is related to their existence in a perivascular niche, which has implications for understanding MSC biology, and for clinical and pharmacological purposes.