Concise Review: MSC Adhesion Cascade—Insights into Homing and Transendothelial Migration
Franziska Nitzsche,Claudia Müller,Barbara Lukomska,Jukka Jolkkonen,Alexander Deten,Johannes Boltze,Johannes Boltze +6 more
TL;DR: In this paper, a detailed overview over the current knowledge of MSC transendothelial migration is provided, using the leukocyte extravasation process as a role model to build a comprehensive concept of mesenchymal stem cell egress mechanisms from the blood stream and identified relevant similarities as well as important differences between the different mechanisms.
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Abstract: Mesenchymal stem cells (MSCs) are promising candidates for adult cell therapies in regenerative medicine To fully exert their potential, efficient homing and migration toward lesion sites play an important role Local transplantation deposits MSC in spatial proximity to the lesion, but often requires invasive procedures Systemic administration routes are favored, but require the targeted extravasation of the circulating MSC at the site of injury Transplanted MSC can indeed leave the blood flow and transmigrate through the endothelial barrier, and reach the lesion site However, the underlying processes are not completely dissolved yet Recent in vitro and in vivo research identified some key molecules scattered light on the extravasation mechanism This review provides a detailed overview over the current knowledge of MSC transendothelial migration We use the leukocyte extravasation process as a role model to build a comprehensive concept of MSC egress mechanisms from the blood stream and identified relevant similarities as well as important differences between the extravasation mechanisms Stem Cells 2017;35:1446-1460
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Citations
In vitro Studies of Transendothelial Migration for Biological and Drug Discovery
Alec T. Salminen,Zahra Allahyari,Shayan Gholizadeh,Molly C McCloskey,Raquel E Ajalik,Renee N. Cottle,Thomas R. Gaborski,Thomas R. Gaborski,James L. McGrath +8 more
- 16 Nov 2020
TL;DR: In vitro studies of TEM showcase the great experimental progress at the lab bench and highlight the historical success of in vitro platforms for biological discovery, and shows the potential for applying these platforms for pharmaceutical compound screening.
Macrophages—bone marrow mesenchymal stem cells crosstalk in bone healing
TL;DR: The role of macrophages and bone marrow mesenchymal stem cells (BMSCs) in bone healing has gradually come to light with the development of the concept of osteoimmunity as discussed by the authors .
Mesenchymal Stromal/Stem Cells and Their Extracellular Vesicles Application in Acute and Chronic Inflammatory Liver Diseases: Emphasizing on the Anti-Fibrotic and Immunomodulatory Mechanisms
TL;DR: The application of MSCs derived EVs, including exosomes, can help treat liver disease and prevent its progression.
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Role of the CXCR4-SDF1-HMGB1 pathway in the directional migration of cells and regeneration of affected organs
Nazmul Haque,Ismail M Fareez,Liew Fong Fong,Chanchal Mandal,Noor Hayaty Abu Kasim,Kranthi Raja Kacharaju,Pratiwi Soesilawati +6 more
TL;DR: The role of different types of cells within the body in facilitating regeneration is described while emphasizing the HMGB1-SDF1-CXCR4 pathway that orchestrates the migration of cells to the site where regeneration is needed.
25
Mesenchymal Stromal Cell Immunology for Efficient and Safe Treatment of Osteoarthritis.
TL;DR: The importance of the immunological features of MSCs, including the type of transplantation and the immune and blood compatibility, are discussed, as well as some of the actions/mechanisms that are displayed during tissue healing including the response of M SCs to injury signals, their interaction with the immune system, and the impact of their lifespan.
References
Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
Massimo Dominici,K. Le Blanc,Ingo Mueller,I. Slaper-Cortenbach,Frank C. Marini,Diane S. Krause,Robert J. Deans,Armand Keating,Darwin J. Prockop,Edwin M. Horwitz +9 more
TL;DR: The Mesenchymal and Tissue Stem Cell Committee of the International Society for Cellular Therapy proposes minimal criteria to define human MSC, believing this minimal set of standard criteria will foster a more uniform characterization of MSC and facilitate the exchange of data among investigators.
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Getting to the site of inflammation: the leukocyte adhesion cascade updated
TL;DR: This Review focuses on new aspects of one of the central paradigms of inflammation and immunity — the leukocyte adhesion cascade.
4.4K
Mesenchymal stem cells reside in virtually all post-natal organs and tissues
TL;DR: The results suggest that the distribution of MSCs throughout the post-natal organism is related to their existence in a perivascular niche, which has implications for understanding MSC biology, and for clinical and pharmacological purposes.