Journal Article10.1021/OL802254Z
Concise enantioselective total synthesis of neopeltolide macrolactone highlighted by ether transfer.
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TL;DR: The present synthesis was highlighted by successful exploitation of ether transfer methodology and a radical cyclization reaction to directly establish the requisite stereochemistry of the tetrahydropyran core.
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About: This article is published in Organic Letters. The article was published on 15 Oct 2008. The article focuses on the topics: Total synthesis.
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Citations
Update 1 of: macrolactonizations in the total synthesis of natural products.
TL;DR: Products A. Parenty,† X. Moreau,†,§ Gilles Niel,‡ and J.-M.
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Thiazole and Oxazole Alkaloids: Isolation and Synthesis
Danilo Davyt,Gloria Serra +1 more
TL;DR: The isolation, synthetic, and biological studies of thiazoles, oxazole and their corresponding reduced derivatives, thiazolines and oxazolines, covering literature from January 2007 to June 2010 are summarized.
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Strategies for the construction of tetrahydropyran rings in the synthesis of natural products
TL;DR: This review focuses on the methodology used for the construction of tetrahydropyran (THP) rings in the synthesis of natural products over the last seven years to provide an overview of the area for those who are unfamiliar, and to refresh and remind those who do work in the area of the exciting developments in the field.
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Enantioselective Alcohol C–H Functionalization for Polyketide Construction: Unlocking Redox-Economy and Site-Selectivity for Ideal Chemical Synthesis
TL;DR: The development and application of stereoselective and site-selective catalytic methods that directly convert lower alcohols to higher alcohols are described, and the total syntheses of several iconic type I polyketide natural products were undertaken.
A Concise Total Synthesis of (+)‐Neopeltolide
TL;DR: In this paper, the title compound (I) showed potent antiproliferative activity against several cancer cell lines and good antifungal activity against Candida albicans.
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D. B. Dess,J. C. Martin +1 more
TL;DR: Conversion de cyclohexanol, octanol, alcool benzylique and des alcools dimethoxy-and trimethoxy benzyliques par oxydation avec le triacetoxy-1, 1, 1 benzoiodoxole-1 2 one-3
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N-methoxy-n-methylamides as effective acylating agents
Steven Nahm,Steven M. Weinreb +1 more
TL;DR: Readily preparable N-methoxy-N-methylamides couple in good yields with Grignard and organolithium reagents to produce ketones, and are reduced with hydrides to afford aldehydes.
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Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae.
Amy E. Wright,Julianne Cook Botelho,Esther A. Guzmán,Dedra Harmody,Patricia Linley,Peter J. McCarthy,Tara P. Pitts,Shirley A. Pomponi,John K. Reed +8 more
TL;DR: Neopeltolide is a potent inhibitor of the in vitro proliferation of the A-549 human lung adenocarcinoma, the NCI-ADR-RES human ovarian sarcoma, and the P388 murine leukemia cell lines, with IC50's of 1.2, 5.1, and 0.56 nM, respectively.
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