Concepts in genetic medicine
Boro Dropulic,Barrie J. Carter +1 more
- 22 Jan 2008
- Iss: 1
TL;DR: Concepts in genetic Medicine , Concepts in genetic medicine , کتابخانه دیجیتال جندی شاپور اهواز
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Abstract: Concepts in genetic medicine , Concepts in genetic medicine , کتابخانه دیجیتال جندی شاپور اهواز
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Absence of Replication-Competent Lentivirus in the Clinic: Analysis of Infused T Cell Products.
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T lymphocyte engineering ex vivo for cancer and infectious disease.
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Highly efficient EIAV-mediated in utero gene transfer and expression in the major muscle groups affected by Duchenne Muscular Dystrophy.
Lisa G. Gregory,Simon N. Waddington,Maxine V. Holder,Kyriacos A. Mitrophanous,Suzanne M. K. Buckley,K. Mosley,Brian W. Bigger,F M Ellard,Lucy E. Walmsley,L Lawrence,Faisal A. Al-Allaf,Susan M. Kingsman,Charles Coutelle,Michael Themis +13 more
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TL;DR: In this article, the authors applied s-galactosidase expressing equine infectious anaemia virus (EIAV) pseudotyped with VSV-G by single or combined injection via different routes to the MF1 mouse fetus on day 15 of gestation and describe substantial gene delivery to the musculature.
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References
•Book
Cancer Chemotherapy and Biotherapy: Principles and Practice
Bruce A. Chabner,Dan L. Longo +1 more
- 01 Apr 1996
TL;DR: Clinical Strategies for Cancer Treatment: The Role of Drugs Preclinical Aspects of Cancer Drug Discovery and Development Pharmacokinetics and Clinical Monitoring Infertility after Cancer Chemotherapy Carcinogenesis: A Late Complication of cancer Chemotherapy Steroid Hormone Therapies for Cancer Antifolates 5-Fluoropyrimidines Cytidine Analogs Purine Antimetabolites Hydroxyurea Antimicrotubule Agents.
468
An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection
Deborah Palliser,Dipanjan Chowdhury,Qing Yin Wang,Sandra J. Lee,Roderick T. Bronson,David M. Knipe,Judy Lieberman +6 more
TL;DR: It is shown that vaginal instillation of small interfering RNAs (siRNAs) targeting HSV-2 protects mice from lethal infection and suggests that siRNAs are attractive candidates for the active component of a microbicide designed to prevent viral infection or transmission.
465
Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery
Nicholas D. Mazarakis,Mimoun Azzouz,Jonathan Rohll,Fiona Margaret Ellard,Fraser J. Wilkes,Anna L. Olsen,Emma E. Carter,Robert D. Barber,Dilair F. Baban,Susan Mary Kingsman,Alan J. Kingsman,Karen L. O'Malley,Kyriacos Mitrophanous +12 more
TL;DR: Long-term expression was observed after gene transfer in the nervous system and a minimal immune response which, together with the possibility of non-invasive administration, greatly extends the utility of lentiviral vectors for gene therapy of human neurological disease.
Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system.
TL;DR: The results demonstrate that both nigral and striatal transduction provide significant protection of nigral DA neurons against the toxin-induced degeneration, and provide evidence that rAAV is a highly efficient vector system for long-term expression of therapeutic proteins in the nigrostriatal system.
455
•Journal Article
Bioactivity of Autologous Irradiated Renal Cell Carcinoma Vaccines Generated by ex Vivo Granulocyte-Macrophage Colony-stimulating Factor Gene Transfer
Jonathan W. Simons,Elizabeth M. Jaffee,Christine E. Weber,Hyam I. Levitsky,William G. Nelson,Michael A. Carducci,Audrey J. Lazenby,Lawrence K. Cohen,Christy C. Finn,Shirley M. Clift,Karen M. Hauda,Lisa A. Beck,Kristin M. Leiferman,Albert H. Owens,Steven Piantadosi,Glenn Dranoff,Richard C. Mulligan,Drew M. Pardoll,Fray F. Marshall +18 more
TL;DR: This Phase I study demonstrated the feasibility, safety, and bioactivity of an autologous GM-CSF gene-transduced tumor vaccine for RCC patients.
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