Journal Article10.1016/J.IJPHARM.2019.118549
Computer-based formulation design and optimization using Hansen solubility parameters to enhance the delivery of ibuprofen through the skin
Bshaer M. Jameel,An Huynh,Aastha Chadha,Sujata Pandey,Jacalyn Duncan,Mark Chandler,Gabriella Baki +6 more
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TL;DR: Emulgels designed and optimized using Formulating for EfficacyTM (FFE) for the topical delivery of ibuprofen had skin compatible pH, viscosity and spreadability comparable to a marketed emulgel, and were opaque and stable at 25°C for 6months.
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About: This article is published in International Journal of Pharmaceutics. The article was published on 05 Oct 2019.
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Citations
Evaluation of Formulation Parameters on Permeation of Ibuprofen from Topical Formulations Using Strat-M® Membrane.
Pradeep Kumar Bolla,Bradley A. Clark,Abhishek Juluri,Hanumanth Srikanth Cheruvu,Jwala Renukuntla +4 more
TL;DR: Findings from this study indicate that pharmaceutical formulation scientists should explore these critical factors during the early development of any new topical drug product in order to meet pre-determined quality target product profile.
106
Transdermal Delivery of Chemotherapeutics: Strategies, Requirements, and Opportunities.
Rabin Neupane,Sai H.S. Boddu,Mariam Sami Abou-Dahech,Rinda Devi Bachu,David Terrero,R. Jayachandra Babu,Amit K. Tiwari +6 more
TL;DR: In this paper, the authors discuss the advantages of transdermal route over oral and parenteral routes for popular chemotherapeutic drugs and also discuss a possible in silico approach, Formulating for Efficacy™, to design trans-dermal formulations that would probably be economical, robust, and more efficacious.
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Gelation properties of various long chain amidoamines: Prediction of solvent gelation via machine learning using Hansen solubility parameters
TL;DR: In this paper, four new amphiphilic long chain amidoamine derivatives displaying different structure variations are synthesized and tested in 27 liquids and compared to the study of two similar molecules already reported in the literature.
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Defining design space for optimization of escitalopram ultra-fast melting tablet using suspension spray-coating technique: In-vitro and in-vivo evaluation
El-Sayed Khafagy,El-Sayed Khafagy,Mohamed H Fayed,Mohamed H Fayed,Sami H. Alrabahi,Shadeed Gad,Saad M. Alshahrani,Mohammed F. Aldawsari +7 more
TL;DR: In this article, a full factorial design was applied to obtain the optimal formulation in terms of; mannitol level (X1) and partially pre-gelatinized starch level (PPGS; X2) as independent formulation variables.
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Long-Term Insect Repellent Electrospun Microfibers from Recycled Poly(ethylene terephthalate).
Ashley C Fulton,Matthew D. Thum,Javier Jimenez,Gerald Camarella,James E Cilek,Jeffrey G. Lundin +5 more
TL;DR: Long-term insect repellent electrospun microfibers from recycled PET offer a novel approach to prevent insect-borne diseases by encapsulating repellents in recycled PET microfibers. The repellent retention and release profiles are high, and the repellency lasts for weeks.
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