Computational Drug Discovery and Repurposing for the Treatment of COVID-19: A Systematic Review

TL;DR: Covering all activities concerned with emergency medicine, it is the journal to turn to for information to help increase the ability to understand, recognize and treat emergency conditions.

TL;DR: In this article, the authors provide an introduction to molecular docking and to the different docking procedures with a focus on several considerations and protocols, including protonation states, active site waters and consensus, that can greatly improve the docking results.

TL;DR: In this paper , a review summarizes representative structures and typically potential therapy agents that target SARS-CoV-2 or some critical proteins for viral pathogenesis, providing insights into the mechanisms underlying viral infection, prevention of infection, and treatment.

TL;DR: A virtual screening procedure employing docking of different databases including 1615 FDA approved drugs was used to identify new potential small molecule inhibitors for protease protein of COVID-19 and indicates that simeprevir (Hepatitis C virus NS3/4A protease inhibitor) could fit well to the binding pocket of protease and might be a helpful treatment option for CO VID-19.

TL;DR: Education is an important aspect in containing the COVID-19 pandemic, as it directly increases adherence of the general public to protective measures.

TL;DR: In this study, the newly emerged 2019-nCoV papain-like protease (PLpro) is targeted by anti-SARS PLpro drugs and the anti-Hepatitis C Virus (HCV) Non-structural protein 3 (NS3) serine protease drugs.

TL;DR: It is to be hoped that the lessons the authors learned from SARS-CoV-2, help us to prevent possible pandemic in the near future and borderless solution is needed to fight COVID-19.