Comprehensive Characterization of Cancer Driver Genes and Mutations.

TL;DR: The current state of knowledge on KDM5 function is reviewed, with a particular emphasis on molecular interactions and their potential implications, including close physical and functional interactions with epigenetic regulators such as histone deacetylase (HDAC) containing complexes, as well as the retinoblastoma protein (RB).

TL;DR: This paper performed whole-exome sequencing of 52 tumor samples from 33 patients with Esophageal squamous cell carcinoma (ESCC) who received radiotherapy combined with 5fluorouracil/platinum.

TL;DR: Five types of RCD pathways are described in detail with respect to tumorigenesis and cancer progression and the potential value of some of these key effector molecules in tumor diagnosis and therapeutic response is raised.

TL;DR: In this article , the authors describe a proof-of-concept study using novel heterobifunctional small molecules called Regulated Induced Proximity Targeting Chimeras or RIPTACs, which elicit a stable ternary complex between a target protein selectively expressed in cancer tissue and a pan-expressed protein essential for cell survival.

TL;DR: The ANNOVAR tool to annotate single nucleotide variants and insertions/deletions, such as examining their functional consequence on genes, inferring cytogenetic bands, reporting functional importance scores, finding variants in conserved regions, or identifying variants reported in the 1000 Genomes Project and dbSNP is developed.

TL;DR: Circos uses a circular ideogram layout to facilitate the display of relationships between pairs of positions by the use of ribbons, which encode the position, size, and orientation of related genomic elements.

TL;DR: The aggregation and analysis of high-quality exome (protein-coding region) DNA sequence data for 60,706 individuals of diverse ancestries generated as part of the Exome Aggregation Consortium (ExAC) provides direct evidence for the presence of widespread mutational recurrence.

TL;DR: It is shown that hypermutation localized to small genomic regions, ‘kataegis’, is found in many cancer types, and this results reveal the diversity of mutational processes underlying the development of cancer.