Composition containing genetically modified propionibacterium acnes, and genetically modified bacteria of propionibacterium acnes strain

TL;DR: In this paper, the authors proposed a method to provide pharmaceutical compositions for a field of dermatology and for topical dermatological purposes, which contain genetically modified bacteria, such as Propionibacterium acnes.

Abstract: To provide pharmaceutical compositions for a field of dermatology and for topical dermatological purposes, the pharmaceutical compositions containing genetically modified bacteria.SOLUTION: This invention relates to pharmaceutical compositions prepared for administration to mammal, wherein: the compositions comprise a genetically modified Propionibacterium acnes strain (P. acnes strain) that contains a control factor operatably connected to a nucleic acid encoding a mammalian growth factor or a mammalian cytokine; the strain expresses the mammalian growth factor or the mammalian cytokine; the P. acnes strain a CRISPR array; and the control factor and the nucleic acid are integrated into a genome of the P. acnes strain.SELECTED DRAWING: None