Journal Article10.1016/0959-437X(93)90015-H
Composite origin of major histocompatibility complex genes.
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TL;DR: Major histocompatibility complex genes have now been cloned from representatives of all vertebrate classes except Agnatha and the recent accumulation of sequence data has given great insight into the course of evolution of these genes.
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About: This article is published in Current Opinion in Genetics & Development. The article was published on 01 Jan 1993. The article focuses on the topics: Gene family & Histocompatibility.
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Citations
The N-End Rule Pathway
TL;DR: The biochemical mechanisms, structures, physiological functions, and small-molecule-mediated regulation of the N-end rule pathway regulates homeostasis of various physiological processes through interaction with small molecules are reviewed.
417
Comparative genomic analysis of the MHC: the evolution of class I duplication blocks, diversity and complexity from shark to man
TL;DR: A complex MHC structure for mammals and a relatively simpler design for nonmammalian animals with a hypothetical prototypic structure for the shark is revealed.
262
Mapping of Mhc class I and class II regions to different linkage groups in the zebrafish, Danio rerio
Jasna Bingulac-Popović,Felipe Figueroa,Akie Sato,William S. Talbot,Stephen L. Johnson,Michael A. Gates,John H. Postlethwait,Jan Klein +7 more
TL;DR: It is demonstrated that in the zebrafish (Danio rerio), a representative of the teleost fishes, the class II loci are divided between two linkage groups which are distinct from the linkage group containing the class I loci, indicating that close linkage of the two regions is not necessary either for regulation of expression or for co-evolution of theclass I and class II Loci.
Primitive synteny of vertebrate major histocompatibility complex class I and class II genes.
Yuko Ohta,Kazuhiko Okamura,E. Churchill McKinney,Simona Bartl,Keiichiro Hashimoto,Martin F. Flajnik +5 more
TL;DR: The results strongly suggest that the primordial duplication giving rise to classical class I and class II occurred in cis, and the close linkage between these two classes of genes has been maintained for at least 460 million years in representatives of most vertebrate taxa.
164
The Implication and Significance of Beta 2 Microglobulin: A Conservative Multifunctional Regulator.
Ling Li,Mei Dong,Xiao-Guang Wang +2 more
TL;DR: This review focuses on the current knowledge on the implication and significance of beta 2 microglobulin (&bgr;2M), a conservative immune molecule in vertebrate animals, and how it or its signaling pathway has been targeted as biomedical or therapeutic tools.
151
References
Similarity of three-dimensional structure between the immunoglobulin domain and the copper, zinc superoxide dismutase subunit.
TL;DR: A striking similarity in three-dimensional structure has been observed in two functionally unrelated, sequentially non-homologous proteins: the immunoglobulin domain and the copper, zinc superoxide dismutase subunit.
162
Extensive MHC variability in cichlid fishes of Lake Malawi.
Dagmar Klein,Hideki Ono,Hideki Ono,Colm O'hUigin,Vladimir Vincek,Tijs Goldschmidt,Jan Klein,Jan Klein +7 more
TL;DR: High sequence variability of class II major histocompatibility complex genes in a sample of species from Lake Malawi provides a set of molecular markers for studying adaptive radiation and should be useful for estimating the size of the population that founded the species flock.
150
Which came first, MHC class I or class II?
TL;DR: The topic of this paper, the origins of MHC proteins, seems too difficult to hope to understand, but an idea that may influence the way one views the evolution of the MHC is introduced.
132
Are invertebrates capable of anticipatory immune responses
TL;DR: Pour comprendre comment les invertebres se defendent contre les parasites, il ne faudrait pas comparer leur systeme de defense a celui des vertebres.
127
Molecular cloning of major histocompatibility complex class I cDNAs from Atlantic salmon ( Salmo salar )
TL;DR: The primary aim of this study was to isolate and characterize expressed MhC molecules in Atlantic salmon, and thereby provide data for further studies on evolutionary and disease aspects of the Mhc and its polymorphism.
126