Composite origin of major histocompatibility complex genes.

TL;DR: In the zebrafish, Danio rerio, the clusters of class I and class II loci reside in different linkage groups, which has implications for the persistence of syntenic relationships, coevolution of loci, and interpretation of the origin of the human/mouse Mhc organization.

TL;DR: This chapter focuses on the appearance and molecular evolution of antibodies and T-cell receptors (TCR), which are the antigen-specific recognition elements of the combinatorial immune system.

TL;DR: The results imply a complex history of gene conversion, recent duplication, or possibly, concerted evolution among multiple loci, although Agph-DAB1, the first genomic Mhc sequence from a bird other than chicken, provides important clues in the quest for locus-specific MhC primers in birds.

TL;DR: The human Major Histocompatibility Complex (MHC) shares similarities with three other chromosome regions in human that could be the vestige of ancestral large scale duplications, which may give rise to the vertebrate MHC by a quick round of gene cis‐duplication and cis‐exon shuffling.

TL;DR: Most of the polymorphic amino acids of the class I histocompatibility antigen, HLA-A2, are clustered on top of the molecule in a large groove identified as the recognition site for processed foreign antigens.

TL;DR: The domain hypothesis was firmly established when the structures of V and C domains were determined to reveal a common fold forming a sandwich of two p-sheets that was stabilized by the conserved disulfide bond.

TL;DR: The atomic models of the complex between rabbit skeletal muscle actin and bovine pancreatic deoxyribonuclease I both in the ATP and ADP forms have been determined byo X-ray analysis at an effective resolution of 2.8 Å and 3 Å.

TL;DR: The Story TheGene: Organismic approach The Gene: Molecular approach The Protein The Antibody The Cell Function The Population Sociology Evolution Index.