Complement evasion by human pathogens
TL;DR: The human immune system has developed an elaborate network of cascades for dealing with microbial intruders, and the complement system is an essential and efficient component of this machinery.
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Abstract: The human immune system has developed an elaborate network of cascades for dealing with microbial intruders. Owing to its ability to rapidly recognize and eliminate microorganisms, the complement system is an essential and efficient component of this machinery. However, many pathogenic organisms have found ways to escape the attack of complement through a range of different mechanisms. Recent discoveries in this field have provided important insights into these processes on a molecular level. These vital developments could augment our knowledge of the pathology and treatment of infectious and inflammatory diseases.
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Citations
Complement: a key system for immune surveillance and homeostasis
TL;DR: An updated view of the function, structure and dynamics of the complement network is described, its interconnection with immunity at large and with other endogenous pathways is highlighted, and its multiple roles in homeostasis and disease are illustrated.
Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus
TL;DR: Structural and functional analysis has identified four distinct classes of surface proteins, of which microbial surface component recognizing adhesive matrix molecules (MSCRAMMs) are the largest class, and targeting them with vaccines could combat S. aureus infections.
Complement regulators and inhibitory proteins.
Peter F. Zipfel,Christine Skerka +1 more
TL;DR: Insight into the mechanisms of complement regulation are crucial for understanding disease pathology and for enabling the development of diagnostic tools and therapies for complement-associated diseases.
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Complement System Part II: Role in Immunity.
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TL;DR: Recent advances in the understanding of the role of complement in physiology and pathology are discussed, showing that complement contributes to a large variety of conditions, far exceeding the classical examples of diseases associated with complement deficiencies.
The complement system.
J. Vidya Sarma,Peter A. Ward +1 more
TL;DR: This review represents an overview of the complement system in an effort to understand the beneficial as well as harmful roles it plays during inflammatory responses.
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