Complement activation in postpartum thyroiditis
Onyebuchi E. Okosieme,Arthur B Parkes,B. McCullough,D. Doukidis,Bryan Paul Morgan,C. J. Richards,John H. Lazarus +6 more
TL;DR: In PPTD, despite the presence of circulating bioactive TPOAbs, the extent of complement activation is inadequate to cause detectable increases in peripheral blood TCC, suggesting that the complement system may not play a major role in P PTD pathogenesis.
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Abstract: Background: Postpartum thyroid dysfunction (PPTD) develops in 50% of pregnant women who have raised levels of circulating thyroid peroxidase autoantibodies (TPOAb) at booking. Although these antibodies are able to activate the complement cascade in vitro, it is not known whether complement activation plays any role in the pathogenesis of this disease.
Aim: To investigate potential and actual activation of the complement system in women with postpartum thyroiditis.
Design: Complement activation was monitored on a weekly basis in 24 postpartum women who had raised TPOAb at 16 weeks gestation, attending an antenatal clinic in Mid‐Glamorgan, Wales.
Methods: ELISA procedures were used to measure both in‐vitro complement C3 activation by TPOAb and circulating terminal complement complexes (TCC) in serum.
Results: Higher levels of bioactive TPOAb activity were seen in women who developed PPTD when compared to those who did not. However, TCC remained undetectable in serum throughout the period of study.
Conclusions: In PPTD, despite the presence of circulating bioactive TPOAbs, the extent of complement activation is inadequate to cause detectable increases in peripheral blood TCC, suggesting that the complement system may not play a major role in PPTD pathogenesis.
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Citations
Medical management of thyroid dysfunction in pregnancy and the postpartum.
TL;DR: Excellent maternal and fetal outcomes can be achieved with appropriate management of thyroid dysfunction in pregnancy with careful control of maternal disease whilst avoiding fetal hypothyroidism.
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Thyroid Derangements in Pregnancy
TL;DR: Proper evaluation, diagnosis and treatment of thyroid deranagements during pregnancy are of outmost importance because unrecognized thyroid dysfunction during pregnancy may cause irreversible alterations in pregnancy outcomes and physical and mental development of fetus and neonate.
Anti-C1q autoantibodies are linked to autoimmune thyroid disorders in pregnant women
Hana Vitkova,Jan Jiskra,Drahomira Springer,Límanová Z,Z. Telička,Jana Bartáková,Marten Trendelenburg,Eliska Potlukova +7 more
TL;DR: Anti‐C1q antibody levels increase during pregnancy in general and even more in the context of AITD, where they correlate with thyroid stimulating hormone levels.
4
PALAVRAS-CHAVE: tIROIdItE Pós- PARtO, gRAvIdEz, PERí OdO Pós- PARtO, tIROIdItE AutOIMuNE, tIROIdE, dOENçA AutOIMuNE tIROIdEIA
Joana Filipa Barreira,Celestino Neves,Cesar Esteves,Luís Delgado,José Luís Medina,Davide Carvalho +5 more
- 01 Jan 2015
TL;DR: This review article aims to systematize the main thyroid dysfunction in the postpartum, the post partum thyroiditis, with emphasis on the most recent guidelines for approach of the pathology.
References
Purification of the human thyroid peroxidase and its identification as the microsomal antigen involved in autoimmune thyroid diseases
TL;DR: It has been demonstrated that sera with anti‐microsomal autoantibodies from patients presenting Graves' or Hashimoto's thyroiditis diseases were able to bind to purified TPO and to inhibit in a dose‐dependent manner the mAb binding to purifiedTPO, suggesting that TPO is the thyroid antigen termed to date the microsomal antigen.
383
Postpartum thyroid dysfunction in Mid Glamorgan
H. Fung,Minosh Kologlu,Kate Collison,Robert A. John,C. J. Richards,Reginald Hall,Alan McGregor +6 more
TL;DR: Thyroid dysfunction, mainly occurring in the first six months post partum, was usually transient and included both destruction induced hyperthyroidism and hypothyroidism.
185
•Journal Article
Presence of the organ-specific 'microsomal' autoantigen on the surface of human thyroid cells in culture: its involvement in complement-mediated cytotoxicity.
TL;DR: Thyroglobulin antibodies failed to stain viable thyroid monolayers, indicating that this protein or possible receptors for it cannot be detected on the cell surface under these conditions, and some thyrotoxicosis sera containing thyroid-stimulating but not microsomal antibodies, gave negative reactions on viable cultures.
177
Postpartum Thyroiditis and Long-Term Thyroid Status: Prognostic Influence of Thyroid Peroxidase Antibodies and Ultrasound Echogenicity
Lakdasa Premawardhana,Arthur B Parkes,F. Ammari,Robert A. John,C. Darke,H. Adams,John H. Lazarus +6 more
TL;DR: These data, representing the longest follow-up of PPTD women, clearly show that the hypothyroid form of P PTD, high TPOAb levels, and a hypoechogenic U/S pattern lead to a high risk (relative risk) of long term thyroid dysfunction.
169
The clinical spectrum of postpartum thyroid disease
John H. Lazarus,Reginald Hall,Sakinah Othman,Arthur B Parkes,C. J. Richards,B. McCulloch,Brian Harris +6 more
TL;DR: Although PPT is usually transient, this condition, and the euthyroid antibody-positive state, may be associated with significant symptomatology, including an increased incidence of minor to moderate depression, which may contribute to improved management of women during the postpartum period.