Comparison of social cognitive functioning in schizophrenia and high functioning autism: More convergence than divergence
TL;DR: Findings provide further support for similarities in social cognition deficits between HFA and schizophrenia, which have a variety of implications for future work on gene–brain–behavior relationships.
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Abstract: Background: Individuals with schizophrenia and individuals with high-functioning autism (HFA) seem to share some social, behavioral and biological features. Although marked impairments in social cognition have been documented in both groups, little empirical work has compared the social cognitive functioning of these two clinical groups. Method: Forty-four individuals with schizophrenia, 36 with HFA and 41 non-clinical controls completed a battery of social cognitive measures that have been linked previously to specific brain regions. Results: The results indicate that the individuals with schizophrenia and HFA were both impaired on a variety of social cognitive tasks relative to the non-clinical controls, but did not differ from one another. When individuals with schizophrenia were divided into negative symptom and paranoid subgroups, exploratory analyses revealed that individuals with HFA may be more similar, in terms of the pattern of social cognition impairments, to the negative symptom group than to the paranoia group. Conclusions: Our findings provide further support for similarities in social cognition deficits between HFA and schizophrenia, which have a variety of implications for future work on gene-brain-behavior relationships
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Citations
Abnormal Brain Activation During Theory of Mind Tasks in Schizophrenia: A Meta-Analysis.
Lisa Kronbichler,Melanie Tschernegg,Anna Isabel Martin,Matthias Schurz,Martin Kronbichler,Martin Kronbichler +5 more
TL;DR: It is suggested that SZ patients simultaneously show over- and under-activation in TOM-related regions and less specialized brain activation in regions linked to TOM and increased activation in attention-related networks suggesting compensatory effects.
Reciprocal Copy Number Variations at 22q11.2 Produce Distinct and Convergent Neurobehavioral Impairments Relevant for Schizophrenia and Autism Spectrum Disorder.
Amy Lin,Ariana Vajdi,Leila Kushan-Wells,Gerhard Helleman,Laura Hansen,Rachel K. Jonas,Maria Jalbrzikowski,Lyle Kingsbury,Armin Raznahan,Carrie E. Bearden,Carrie E. Bearden +10 more
TL;DR: Cognitive deficits were observed in both CNV groups, with the lowest IQs in deletion carriers, and processing speed impairments implicate aberrant development of the cortical mantle in the pathology underlying impaired processing speed ability.
Reading Emotions from Body Movement: A Generalized Impairment in Schizophrenia
Anja Vaskinn,Anja Vaskinn,Kjetil Sundet,Kjetil Sundet,Tiril Østefjells,Tiril Østefjells,Katharina Sørvang Nymo,Katharina Sørvang Nymo,Ingrid Melle,Ingrid Melle,Torill Ueland,Torill Ueland +11 more
TL;DR: Results showed that persons with schizophrenia had impaired body language reading ability compared to healthy persons and a significant effect of emotion indicated that some emotions were easier to recognize and this was so for both individuals with schizophrenia and healthy individuals.
Predictors of social functioning and quality of life in schizophrenia and autism spectrum disorder.
Silvia Corbera,Silvia Corbera,Bruce E. Wexler,Morris D. Bell,Godfrey D. Pearlson,Sophy Mayer,Brian Pittman,Vaishali Belamkar,Michal Assaf +8 more
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MDMA for the Treatment of Negative Symptoms in Schizophrenia
Mitchell Arnovitz,Andrew J. Spitzberg,Ashkhan Davani,Nehal P. Vadhan,J Holland,John M. Kane,Timothy I. Michaels +6 more
TL;DR: This review provides a rationale for the use of MDMA in the treatment of negative symptoms by reviewing the literature on negative symptoms, their treatment, MDMA, and MDMA-assisted therapy and concludes with considerations regarding safety and possible mechanisms of action.
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