Journal Article10.1007/S11055-005-0155-5
Comparative analysis of cognitive impairments in lewy body dementia and Alzheimer's disease.
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TL;DR: In patients with dementias of similar severities, patients with LBD showed greater impairment of executive and visuospatial functions and had more marked neurodynamic dysfunction.
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Abstract: Neuropsychological studies of 50 patients with Lewy body dementia (LBD) and 50 patients with Alzheimer's disease (AD) were performed to assess the characteristics of the cognitive impairments in these diseases. In patients with dementias of similar severities, patients with LBD showed greater impairment of executive and visuospatial functions and had more marked neurodynamic dysfunction. Patients with AD showed more profound memory disorders.
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Citations
Prodromal clinical manifestations of neuropathologically confirmed Lewy body disease
Greg Jicha,F. A. Schmitt,E. Abner,Peter T. Nelson,Gregory E. Cooper,Charles D. Smith,William R. Markesbery +6 more
TL;DR: The data demonstrate the feasibility of differentiating underlying pathologic processes responsible for cognitive decline in the preclinical disease state and suggest that further refinement in diagnostic criteria may allow more accurate early detection of prodromal DLB and AD.
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Neuropathological associates of multiple cognitive functions in two community-based cohorts of older adults.
N. Maritza Dowling,Sarah E Tomaszewski Farias,Bruce R Reed,Bruce R Reed,Joshua A. Sonnen,Milton E. Strauss,Julie A. Schneider,David A. Bennett,Dan M Mungas +8 more
TL;DR: Results show that cognition is complexly determined by multiple disease substrates, and neuropathological variables and brain weight contributed approximately a third to half of the explained variance in different cognitive domains.
Testing Visual Perception in Dementia with Lewy Bodies and Alzheimer Disease
Joshua S Wood,Michael J. Firbank,Urs Peter Mosimann,Urs Peter Mosimann,Rosie Watson,Robert Barber,Andrew M. Blamire,John T. O'Brien +7 more
TL;DR: Visuoperceptual deficits can be detected in both DLB and AD participants using the NEVIP, with the DLB group performing significantly worse than AD.
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A predominance of category deficits for living things in Alzheimer's disease and Lewy body dementia
TL;DR: Like some AD patients, some DLB patients showed evidence of category-specific naming deficits, and strikingly, all 25 significant category dissociations were for living things.
Two distinct pathological substrates associated with MMSE-pentagons item deficit in DLB and AD.
Luca Beretta,Silvia Paola Caminiti,Roberto Santangelo,Giuseppe Magnani,Francesca Ferrari-Pellegrini,Paolo Caffarra,Daniela Perani +6 more
TL;DR: It is proposed that the inabilities to perform correctly the QSPT task is related to altered visuoperceptual process in DLB, and visuospatial process in AD, which is consistent with the results showing hypometabolism in brain system related to visu operceptual processing.
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References
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Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
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Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB) Report of the consortium on DLB international workshop
Ian G. McKeith,Douglas Galasko,Kenji Kosaka,Elaine K. Perry,Dennis W. Dickson,L. A. Hansen,David P. Salmon,James Lowe,Suzanne S. Mirra,E. J. Byrne,Graham Lennox,Niall Quinn,J.A. Edwardson,Paul G. Ince,Catherine Bergeron,Alistair Burns,Bruce L. Miller,Simon Lovestone,Daniel Collerton,E. N. H. Jansen,Clive Ballard,R. A. I. De Vos,Gordon K. Wilcock,Kurt A. Jellinger,Robert H. Perry +24 more
TL;DR: This work identified progressive disabling mental impairment progressing to dementia as the central feature of DLB, and identified optimal staining methods for each of these and devised a protocol for the evaluation of cortical LB frequency based on a brain sampling procedure consistent with CERAD.
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•Book
Dementia With Lewy Bodies
Ian G. McKeith
- 11 Dec 2011
TL;DR: The current state of scientific knowledge on DLB is reviewed to show that treatment with cholinesterase inhibitors is well tolerated by most patients and substantially improves cognitive and neuropsychiatric symptoms.
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Visual hallucinations in Lewy body disease relate to Lewy bodies in the temporal lobe.
TL;DR: Cognitive fluctuations and/or visual hallucinations were not good predictors of DLB in pathologically proven patients, although the absence of these features early in the disease course was highly predictive of PDD.
Prospective validation of consensus criteria for the diagnosis of dementia with Lewy bodies.
Ian G. McKeith,Clive Ballard,Robert H. Perry,Paul G. Ince,John T. O'Brien,David Neill,K. Lowery,Evelyn Jaros,Robert Barber,Peter L. Thompson,Alan C. Swann,Andrew Fairbairn,Elaine K. Perry +12 more
TL;DR: The Consensus criteria for DLB performed as well in this prospective study as those for AD and VaD, with a diagnostic sensitivity substantially higher than that reported by previous retrospective studies.
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