Common immunopathogenesis of central nervous system diseases: the protein-homeostasis-system hypothesis
TL;DR: The protein-homeostasis-system (PHS) hypothesis as mentioned in this paper proposes that the immune systems in the host control those substances according to the size and biochemical properties of the substances.
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Abstract: There are hundreds of central nervous system (CNS) diseases, but there are few diseases for which the etiology or pathogenesis is understood as well as those of other organ-specific diseases. Cells in the CNS are selectively protected from external and internal insults by the blood-brain barrier. Thus, the neuroimmune system, including microglia and immune proteins, might control external or internal insults that the adaptive immune system cannot control or mitigate. The pathologic findings differ by disease and show a state of inflammation that reflects the relationship between etiological or inflammation-inducing substances and corresponding immune reactions. Current immunological concepts about infectious diseases and infection-associated immune-mediated diseases, including those in the CNS, can only partly explain the pathophysiology of disease because they are based on the idea that host cell injury is caused by pathogens. Because every disease involves etiological or triggering substances for disease-onset, the protein-homeostasis-system (PHS) hypothesis proposes that the immune systems in the host control those substances according to the size and biochemical properties of the substances. In this article, I propose a common immunopathogenesis of CNS diseases, including prion diseases, Alzheimer's disease, and genetic diseases, through the PHS hypothesis.
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References
Astrocyte physiopathology: At the crossroads of intercellular networking, inflammation and cell death
TL;DR: It seems that a better understanding of the mechanisms governing the integrated communication and detrimental responses of the astrocytes as well as their impact towards the homeostasis and performance of the CNS is fundamental to open novel therapeutic perspectives.
183
Major histocompatibility complex class I proteins in brain development and plasticity.
TL;DR: This review summarizes the current understanding of MHCI expression and function in the CNS, as well as the potential mechanisms used by M HCI to regulate brain development and plasticity.
179
Neuronal regulation of immunity: why, how and where?
TL;DR: This Review discusses regulation of immune responses by the nervous system, the benefits of neuronal regulation of immunity, the mechanisms involved and the brain areas involved in neuro-immune crosstalk.
178
Epigenetics as a mechanism linking developmental exposures to long-term toxicity
Robert Barouki,Robert Barouki,Erik Melén,Zdenko Herceg,J Beckers,Jia Chen,Margaret R. Karagas,Alvaro Puga,Y Xia,L Chadwick,W Yan,Karine Audouze,Rémy Slama,J.J. Heindel,Philippe Grandjean,Toshihiro Kawamoto,K Nohara +16 more
TL;DR: A number of criteria are proposed that are critical to support the primary contribution of epigenetics in DOHaD and intergenerational transmission of environmental stressors effects as well as providing insight for future research.
168
Parkinson's Disease Is Not Simply a Prion Disorder
TL;DR: The notion that prion-like spreading of misfolded α-synuclein causes Parkinson's disease has received a great deal of attention but is difficult to reconcile with postmortem analysis of human brains and connectome-mapping studies.
168