Commentary: minimum reporting standards should be expected for preclinical radiobiology irradiators and dosimetry in the published literature.
François Trompier,Larry A DeWerd,Yannick Poirier,Morgane Dos Santos,Ke Sheng,Keith A Kunugi,Thomas A Winters,Andrea L. DiCarlo,Merriline M. Satyamitra +8 more
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TL;DR: Minimum reporting standards for preclinical radiobiology irradiators and dosimetry should be implemented to ensure accurate, precise and reproducible dosimetry.
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Abstract: The cornerstones of science advancement are rigor in performing scientific research, reproducibility of research findings and unbiased reporting of design and results of the experiments. For radiation research, this requires rigor in describing experimental details as well as the irradiation protocols for accurate, precise and reproducible dosimetry. Most institutions conducting radiation biology research in in vitro or animal models do not have describe experimental irradiation protocols in sufficient details to allow for balanced review of their publication nor for other investigators to replicate published experiments. The need to increase and improve dosimetry standards, traceability to National Institute of Standards and Technology (NIST) standard beamlines, and to provide dosimetry harmonization within the radiation biology community has been noted for over a decade both within the United States and France. To address this requirement subject matter experts have outlined minimum reporting standards that should be included in published literature for preclinical irradiators and dosimetry.
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Citations
Minimum reporting standards about dosimetry of radiation sources used in radiation research studies.
Andrzej Wojcik,Isabelle Thierry-Chef,Anna A. Friedl,Werner Rühm +3 more
TL;DR: The editors of Radiation and Environmental Biophysics reproduce the agreed minimum irradiation parameters that should be reported in publications on radiation biology submitted to the authors' journal.
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TL;DR: The meeting focused on understanding and managing radiation-induced gastrointestinal and cutaneous injuries, exploring new research avenues for medical countermeasures, and improving clinical practices. Collaborative projects were established and dosimetry standardization was emphasized.
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Dosimetry: Was and Is an Absolute Requirement for Quality Radiation Research
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TL;DR: This review traces the evolution of dosimetry, highlighting its significance in radiation research, and identifies current trends and methodologies, emphasizing the importance of accurate and reproducible dosimetry in enhancing radiation research quality and practical applications.
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X-ray and DNA Damage: Limitations of the Dose as a Parameter for In Vitro Studies
Ion Udroiu,Antonella Sgura +1 more
TL;DR: It is confirmed that both the dose rate and photon energy influence the effectiveness of an X-ray, and underline the limitations of using the dose as the sole parameter for in vitro studies.
Multiple approaches for dosimetric characterization of a preclinical in vivo micro scanner: complementarity of experimental and numerical dose estimation
Trompier, François,l’Homme Bruno,Gruel Gaetan,Dos Santos Morgane +3 more
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References
The Importance of Dosimetry Standardization in Radiobiology
Marc F. Desrosiers,Larry A. DeWerd,James Deye,Patricia Lindsay,Mark K. Murphy,Michael G. Mitch,Francesca Macchiarini,Strahinja Stojadinovic,Helen Stone +8 more
TL;DR: This workshop did not address issues of dosimetry for studies involving radiation focused at the sub-cellular level, internally-administered radionuclides, biodosimetry based on biological markers of radiation exposure, or dose reconstruction for epidemiological studies.
A Dose of Reality: How 20 Years of Incomplete Physics and Dosimetry Reporting in Radiobiology Studies May Have Contributed to the Reproducibility Crisis.
E. Draeger,Amit Sawant,Christopher Daniel Johnstone,Brandon Koger,Stewart J. Becker,Zeljko Vujaskovic,Isabel-Lauren Jackson,Yannick Poirier +7 more
TL;DR: The first large-scale literature review of the current state of reporting of essential experimental physics and dosimetry details in the scientific literature shows a crucial deficiency in the reporting of basic experimental details and severely impact the reproducibility and translatability of a large proportion of radiation biology studies.
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Transitioning from Gamma Rays to X Rays for Comparable Biomedical Research Irradiations: Energy Matters
TL;DR: Many studies in biomedical research and various allied fields, in which cells or laboratory animals are exposed to radiation, rely on adequate radiation dose standardization for reproducibility and comparability of biological data and a growing number of researchers have considered transferring their studies to kilovoltage X-ray irradiators.
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Investigation of the influence of calibration practices on cytogenetic laboratory performance for dose estimation.
François Trompier,M. Baumann,Lleonard Barrios,Eric Gregoire,Michael Abend,Elizabeth A. Ainsbury,Stephen Barnard,Joan Francesc Barquinero,Juan Antonio Bautista,Beata Brzozowska,Jose Perez-Calatayud,Cinzia De Angelis,Inmaculada Domínguez,Valeria Hadjidekova,Ulrike Kulka,Juan Carlos Rodríguez Mateos,Roberta Meschini,Octávia Monteiro Gil,Jayne Moquet,Ursula Oestreicher,Alegria Montoro Pastor,Roel Quintens,Natividad Sebastià,Sylwester Sommer,Orlin Stoyanov,Hubert Thierens,Georgia I. Terzoudi,J. I. Villaescusa,Anne Vral,Andrzej Wojcik,D. Zafiropoulos,Laurence Roy +31 more
TL;DR: The re-evaluation of some ILC results for the fluorescence in situ hybridization (FISH) and premature chromosome condensation (PCC) assays has been performed leading to an improvement of the overall performances, showing the importance of dosimetry in radiobiology studies and the needs of harmonization, standardization in irradiation and Dosimetry practices and educational training for biologists using ionizing radiation.
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Principles and techniques of mixed radiation dosimetry. application to acute lethality studies of mice with the cyclotron
TL;DR: In this article, the authors enumerate some of the factors governing the physical dose and elaborate on the best methods for measuring them, and a careful study was made of the dose inside an animal exposure facility at the Oak Ridge National Laboratory 86-inch cyclotron.
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