Combining EEG and fMRI: A multimodal tool for epilepsy research
TL;DR: The methodology involved in performing such studies, particularly the challenge of recording a good quality EEG inside the MR scanner while scanning is taking place, and the methods required for the statistical analysis of the combined EEG and fMRI time series are reviewed.
read more
Abstract: Patients with epilepsy often present in their electroencephalogram (EEG) short electrical potentials (spikes or spike-wave bursts) that are not accompanied by clinical manifestations but are of important diagnostic significance They result from a population of abnormally hyperactive and hypersynchronous neurons It is not easy to determine the location of the cerebral generators and the other brain regions that may be involved as a result of this abnormal activity The possibility to combine EEG recording with functional MRI (fMRI) scanning opens the opportunity to uncover the regions of the brain showing changes in the fMRI signal in response to epileptic spikes seen in the EEG These regions are presumably involved in the abnormal neuronal activity at the origin of epileptic discharges This paper reviews the methodology involved in performing such studies, particularly the challenge of recording a good quality EEG inside the MR scanner while scanning is taking place, and the methods required for the statistical analysis of the combined EEG and fMRI time series We review the results obtained in patients with different types of epileptic disorders and discuss the difficult theoretical problems raised by the interpretation of an increase (activation) and decrease (deactivation) in blood oxygen level dependent (BOLD) signal, both frequently seen in response to spikes
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
EEG and MEG: relevance to neuroscience
TL;DR: The relevance of EEG/MEG signals to obtain novel insights into the neuronal mechanisms underlying cognitive processes is surveyed, with emphasis on neuronal oscillations (ultra-slow, theta, alpha, beta, gamma, and HFOs) and combinations of oscillations.
869
Identifying neural drivers with functional MRI: an electrophysiological validation.
Olivier David,Isabelle Guillemain,Sandrine Saillet,Sebastien Reyt,Colin Deransart,Christoph Segebarth,Antoine Depaulis +6 more
TL;DR: The first experimental substantiation of the theoretical possibility to improve interregional coupling estimation from hidden neural states of fMRI is provided, which has important implications for future studies on brain connectivity using functional neuroimaging.
Review on solving the forward problem in EEG source analysis
Hans Hallez,Bart Vanrumste,Bart Vanrumste,Roberta Grech,Joseph Muscat,Wim De Clercq,Anneleen Vergult,Yves D'Asseler,Kenneth P. Camilleri,Simon G. Fabri,Sabine Van Huffel,Ignace Lemahieu +11 more
TL;DR: This review article focuses on different aspects of solving the forward problem of electroencephalogram source localization and introduces the use of reciprocity to speed up the forward calculations.
Altered Functional Connectivity and Small-World in Mesial Temporal Lobe Epilepsy
Wei-Ting Liao,Zhiqiang Zhang,Zhengyong Pan,Dante Mantini,Dante Mantini,Jurong Ding,Xujun Duan,Cheng Luo,Guangming Lu,Huafu Chen +9 more
TL;DR: The mTLE alterations observed in functional connectivity and topological properties may be used to define tentative disease markers, including altered small-world properties in patients, along with smaller degree of connectivity, increased n-to-1 connectivity, smaller absolute clustering coefficients and shorter absolute path length.
Dynamic time course of typical childhood absence seizures: EEG, behavior, and functional magnetic resonance imaging.
Xiaoxiao Bai,Matthew Vestal,Rachel Berman,Michiro Negishi,Marisa N. Spann,Clemente Vega,Matthew N. DeSalvo,Edward J. Novotny,Robert Todd Constable,Hal Blumenfeld +9 more
TL;DR: In this article, the authors acquired simultaneous EEG-fMRI in 88 typical childhood absence seizures from nine pediatric patients and investigated behavior concurrently using a continuous performance task or simpler repetitive tapping task.
305
References
Interictal and ictal dipole modelling in patients with refractory partial epilepsy
Paul Boon,M. D'Havé +1 more
TL;DR: Spike voltage topography and corresponding dipole mapping provided additional and reliable information that was relevant in surgical candidates for refractory partial epilepsy, e.g. by suggesting in some patients that the medial temporal structures were not primarily involved.
57
Hemodynamic and metabolic aspects of photosensitive epilepsy revealed by functional magnetic resonance imaging and magnetic resonance spectroscopy.
TL;DR: To study in humans the hemodynamic and metabolic consequences of both photic stimulationtriggered and spontaneous generalized epileptiform discharges.
56
Hemodynamic changes in simple partial epilepsy : A functional MRI study
Timo Krings,Rudolf Töpper,M. H. T. Reinges,H. Foltys,Uwe Spetzger,Keith H. Chiappa,Joachim M. Gilsbach,Armin Thron +7 more
TL;DR: It might be possible to use fMRI as a noninvasive tool to detect and investigate cortical patterns of activation associated with seizure activity in selected patients, because it has shown that epileptic activity leads to changes in cerebral hemodynamics.
56
Mapping of spikes, slow waves, and motor tasks in a patient with malformation of cortical development using simultaneous EEG and fMRI.
TL;DR: Continuous EEG-fMRI is useful to compare the functional mapping of epileptiform activity and eloquent cortices in individual patients.
54
Assessing the relevance of fMRI-based prior in the EEG inverse problem: a bayesian model comparison approach
Jean Daunizeau,Christophe Grova,Jérémie Mattout,Guillaume Marrelec,Diego Clonda,B. Goulard,M. Pelegrini-Issac,Jean-Marc Lina,H. Benali +8 more
TL;DR: A Bayesian characterization of the relevance of fMRI-derived prior information regarding the EEG/MEG data is proposed by quantifying the adequacy of this prior to the data, compared with that obtained using an noninformative prior instead.
53