Journal Article10.1016/0005-2795(76)90048-9
Collagen heterogeneity in pig heart valves
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TL;DR: The collagenic web of this tissue is highly polymerized, which explains the inability to solubilize all of the collagen molecules and the presence of high-molecular-weight molecules in the pepsin-soluble fractions.
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About: This article is published in Biochimica et Biophysica Acta. The article was published on 20 May 1976. The article focuses on the topics: Type I collagen.
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Citations
Tissue heart valves: Current challenges and future research perspectives
TL;DR: Tissue valve mineralization has complex host, implant, and mechanical determinants and degradation mechanisms are largely rationalized on the basis of the changes to natural valves when they are fabricated into a tissue valve, and the subsequent interactions with the physiologic environment that are induced following implantation.
516
Patent
Treated tissue for implantation and methods of preparation
Steven Goldstein
- 05 Jun 1995
TL;DR: In this paper, a method for generating functional hybrid bioprosthesis is described, in which a tissue formed naturally of interstitial collagens is treated to kill native cells and remove potentially immunologically active soluble molecules, and then it may be treated sequentially with extracellular matrix adhesion factor, extacellular matrix glycosaminoglycan, and growth factor appropriate to the cell type required to function within the matrix.
225
Patent
Treated tissue for implantation and methods of treatment and use
E. Christopher Orton
- 05 Mar 1991
TL;DR: The preferred growth factor is basic fibroblast growth factor, and the preferred cells are fibroblasts as discussed by the authors, which can be an allograft or xenograft taken from a cow, pig or other mammal.
151
•Journal Article
Calcification of subcutaneously implanted type I collagen sponges. Effects of formaldehyde and glutaraldehyde pretreatments.
TL;DR: It is concluded that both glutaraldehyde- and formaldehyde-pretreated Type I collagen sponges calcify after subdermal implantation in young rats, and the threshold level of aldehyde-induced cross-linking required to potentiate their maximal pathologic calcification is low.
139
Porcine cardiac valvular subendothelial cells in culture: cell isolation and growth characteristics.
TL;DR: It is concluded that valve subendothelial cells show features that distinguish them from other cultured mesenchymal cells, and that this culture system will be useful for studies of the cellular basis of valvular heart disease.
110
References
[α1(III)]3 Human Skin Collagen RELEASE BY PEPSIN DIGESTION AND PREPONDERANCE IN FETAL LIFE
TL;DR: The relative quantities of these peptides indicate that α1(III) chains predominate in early fetal skin, but by birth and in later lifeα1(I) chains are approximately 3 times as plentiful.
591
Identification of three genetically distinct collagens by cyanogen bromide cleavage of insoluble human skin and cartilage collagen.
TL;DR: Characterization of peptides derived from collagen permit the identification of an additional type of collagen in skin and yet another type in cartilage, and results indicate that the new types of collagen are comprised of chains homologous to the α1 chain of soluble human skin collagen.
304
Human aorta collagens: Evidence for three distinct species
TL;DR: Three different molecular species of collagen and a soluble form of elastin were obtained by digestion of human aortas with pepsin, and appear to represent type IV collagen previously described in basement membranes and type III collagen, recently found in fetal skin.
161
Occurrence of type III collagen in inflamed synovial membranes: a comparison between non rheumatoid, rheumatoid, and normal synovial collagens.
Jacqueline B. Weiss,C.A. Shuttleworth,Robert A. Brown,K. Sedowfia,A. Baildam,JohnA.A. Hunter +5 more
TL;DR: Comparison of normal, rheumatoid and inflamed synovia has shown that abnormal amounts of Type III collagen can be isolated from r heumatoid or inflamedsynovia, either after digestion of the tissues with pepsin or as an abnormal polymeric form (F2PC) accounting for 10–15% of total polymeric collagen after EDTA treatment.
54
Synthesis of type III collagen by embryonic chick skin
TL;DR: Analysis of cyanogen bromide peptides from the α1 chains synthesized by lathyritic embryonic chick skin during short-term tissue culture revealed significant levels of both Types I and III collagen prior to thirteen days of development, but mainly Type I collagen thereafter.
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