Journal Article10.1007/S00406-020-01121-2
Cognitive outcomes of the bipolar depression electrical treatment trial (BETTER): a randomized, double-blind, sham-controlled study
Gabriel Tortella,Bernardo Sampaio-Junior,Marina Moreno,Adriano H. Moffa,Adriano Fernandes da Silva,Beny Lafer,Paulo A. Lotufo,Wagner F. Gattaz,Lucas Borrione,Rodrigo Machado-Vieira,Stephan Goerigk,Isabela M. Benseñor,Andre R. Brunoni +12 more
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TL;DR: No significant differences between groups over 6 weeks of treatment were observed for any cognitive outcomes and the findings warrant further replication in larger studies.
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Abstract: Bipolar depression is associated with marked cognitive deficits. Pharmacological treatments for this condition are limited and may aggravate depressive and cognitive symptoms. Therefore, therapeutic interventions that preserve adequate cognitive functioning are necessary. Our previous results demonstrated significant clinical efficacy of transcranial direct current stimulation (tDCS) in the Bipolar Depression Electrical Treatment Trial (BETTER). Here, cognitive outcomes of this study are reported. We randomized 59 patients with bipolar disorder I or II in an acute depressive episode to receive active (12 2 mA, 30-min, anodal-left, cathodal-right prefrontal cortex tDCS sessions) or sham tDCS. Patients were on stable pharmacological regimen for at least 2 weeks. A battery of 12 neuropsychological assessments in five cognitive domains (attention and processing speed, memory, language, inhibitory control, and working memory and executive function) was performed at baseline, after two weeks and at endpoint (week 6). No significant differences between groups over 6 weeks of treatment were observed for any cognitive outcomes. Moreover, no decrease in cognitive performance was observed. Our findings warrant further replication in larger studies. Trial Registration: clinicaltrials.gov Identifier: NCT02152878
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Citations
Neural network of bipolar disorder: Toward integration of neuroimaging and neurocircuit-based treatment strategies
Bo Bi,Dongfang Che,Yuyin Bai +2 more
TL;DR: In this article , the authors proposed a neurocircuit-based clinical characteristics and taxonomy to guide the treatment of bipolar disorder, based on findings from neuropsychological and neuroimaging studies.
Brain stimulation treatment for bipolar disorder
TL;DR: In this paper , the authors provide an up-to-date overview of research on the efficacy, tolerability and cognitive effects of electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), transcransranial direct current stimulation (tDCS), magnetic seizure therapy (MST), deep brain stimulation (DBS) and vagus nerve stimulation (VNS).
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Can brain stimulation enhance cognition in clinical populations? A critical review.
TL;DR: A review of the current clinical evidence for brain stimulation treatments as therapeutics for enhancing cognition is presented in this paper , together with potential putative neural mechanisms to assist with optimization of these approaches.
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Cognitive Effects of Transcranial Direct Current Stimulation in Clinical Trials
Donel Martin,Adriano H. Moffa +1 more
- 01 Jan 2021
TL;DR: In this paper, the authors describe the effects of tDCS on cognition, as reported in modern clinical trials and provide an overview and discussion of acute and potential lasting neurocognitive effects.
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