Journal Article10.1126/SCIENCE.ABB0738
Clocks, cancer, and chronochemotherapy
TL;DR: Although the results of many epidemiologic and animal studies are consistent with there being a role for the clock in the genesis and progression of tumors, available data are insufficient to conclude that clock disruption is generally carcinogenic as mentioned in this paper.
read more
Abstract: The circadian clock coordinates daily rhythmicity of biochemical, physiologic, and behavioral functions in humans. Gene expression, cell division, and DNA repair are modulated by the clock, which gives rise to the hypothesis that clock dysfunction may predispose individuals to cancer. Although the results of many epidemiologic and animal studies are consistent with there being a role for the clock in the genesis and progression of tumors, available data are insufficient to conclude that clock disruption is generally carcinogenic. Similarly, studies have suggested a circadian time-dependent efficacy of chemotherapy, but clinical trials of chronochemotherapy have not demonstrated improved outcomes compared with conventional regimens. Future hypothesis-driven and discovery-oriented research should focus on specific interactions between clock components and carcinogenic mechanisms to realize the full clinical potential of the relationship between clocks and cancer.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Learning from circadian rhythm to transform cancer prevention, prognosis, and survivorship care.
Xiaoyan Zhu,Geraldine Maier,Satchidananda Panda +2 more
TL;DR: Monitoring circadian factors aids risk assessment and targeted interventions across the cancer care continuum, and understanding circadian control of metabolism informs timing for therapies to reduce adverse effects and enhance treatment efficacy.
18
The Time for Chronotherapy in Radiation Oncology.
TL;DR: A review of the main advances in the field of chronoradiotherapy, the possible causes of the inconsistencies observed in the studies so far and provide some recommendations for future trials can be found in this article.
Normalized coefficient of variation (nCV): a method to evaluate circadian clock robustness in population scale data.
TL;DR: Gong et al. as discussed by the authors showed that the normalized coefficient of variation (nCV) of 10 clock genes is linearly correlated with their normalized rAMP, independent of time labels.
18
Circadian Biology in Obstructive Sleep Apnea.
Bala S C Koritala,Zachary Conroy,David F. Smith +2 more
- 13 Jun 2021
TL;DR: In this article, the authors summarize the pre-existing knowledge of circadian biology in patients with OSA and examine the utility of circadian biomarkers as alternative clinical tools for diagnosis and treatment of OSA.
18
Health benefits of dietary chronobiotics: beyond resynchronizing internal clocks
TL;DR: In this article, a review of the potential mechanisms for the prevention and treatment of metabolic disorders related to circadian misalignment is presented. And the bioactive components of functional foods discussed in this review could be considered potentially effective factors for preventive and treatment.
17
References
Coordination of circadian timing in mammals
TL;DR: Circadian rhythms are generated by one of the most ubiquitous and well-studied timing systems and are tamed by a master clock in the brain, which coordinates tissue-specific rhythms according to light input it receives from the outside world.
4.3K
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
Fred W. Turek,Corinne E. Joshu,Corinne E. Joshu,Akira Kohsaka,Akira Kohsaka,Emily Lin,Emily Lin,Ganka Ivanova,Ganka Ivanova,Erin L. McDearmon,Erin L. McDearmon,Aaron D. Laposky,Sue Losee-Olson,Amy Easton,Dalan R. Jensen,Robert H. Eckel,Joseph S. Takahashi,Joseph S. Takahashi,Joseph Bass,Joseph Bass +19 more
TL;DR: Estimation of transcripts encoding selected hypothalamic peptides associated with energy balance was attenuated in the Clock mutant mice, suggesting that the circadian clock gene network plays an important role in mammalian energy balance.
Transcriptional architecture of the mammalian circadian clock
TL;DR: Genome-wide analyses of the clock transcriptional feedback loop have revealed a global circadian regulation of processes such as transcription factor occupancy, RNA polymerase II recruitment and initiation, nascent transcription, and chromatin remodelling.
Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet
Megumi Hatori,Christopher Vollmers,Amir Zarrinpar,Amir Zarrinpar,Luciano DiTacchio,Eric A. Bushong,Shubhroz Gill,Mathias Leblanc,Amandine Chaix,Matthew S. Joens,James A. J. Fitzpatrick,Mark H. Ellisman,Satchidananda Panda +12 more
TL;DR: Mice under tRF consume equivalent calories from HFD as those with ad lib access yet are protected against obesity, hyperinsulinemia, hepatic steatosis, and inflammation and have improved motor coordination.
1.7K
Systematic Review of the Empirical Evidence of Study Publication Bias and Outcome Reporting Bias
Kerry Dwan,Douglas G. Altman test,Juan A. Arnaiz,Jill Bloom,An-Wen Chan,Eugenia Cronin,Evelyne Decullier,Philippa Easterbrook,Erik von Elm,Erik von Elm,Carrol Gamble,Davina Ghersi,John P. A. Ioannidis,John P. A. Ioannidis,John Simes,Paula R Williamson +15 more
TL;DR: There is strong evidence of an association between significant results and publication; studies that report positive or significant results are more likely to be published and outcomes that are statistically significant have higher odds of being fully reported.