Journal Article10.1126/SCIENCE.ABB0738
Clocks, cancer, and chronochemotherapy
TL;DR: Although the results of many epidemiologic and animal studies are consistent with there being a role for the clock in the genesis and progression of tumors, available data are insufficient to conclude that clock disruption is generally carcinogenic as mentioned in this paper.
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Abstract: The circadian clock coordinates daily rhythmicity of biochemical, physiologic, and behavioral functions in humans. Gene expression, cell division, and DNA repair are modulated by the clock, which gives rise to the hypothesis that clock dysfunction may predispose individuals to cancer. Although the results of many epidemiologic and animal studies are consistent with there being a role for the clock in the genesis and progression of tumors, available data are insufficient to conclude that clock disruption is generally carcinogenic. Similarly, studies have suggested a circadian time-dependent efficacy of chemotherapy, but clinical trials of chronochemotherapy have not demonstrated improved outcomes compared with conventional regimens. Future hypothesis-driven and discovery-oriented research should focus on specific interactions between clock components and carcinogenic mechanisms to realize the full clinical potential of the relationship between clocks and cancer.
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"time" for obesity-related cancer: the role of the circadian rhythm in cancer pathogenesis and treatment.
Caterina Miro,A. Docimo,Luigi Barrea,L. Verde,Simona Cernea,Antoan Stefan Sojat,Ljiljana Marina,Giovanni Docimo,Annamaria Colao,Monica Dentice,Giovanna Muscogiuri +10 more
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Major roles of the circadian clock in cancer
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Circadian Rhythms and Astrocytes: The Good, the Bad, and the Ugly.
TL;DR: A review explores the interface between circadian timekeeping and the regulation of brain function by astrocytes in this article , which is most evident in the central circadian pacemaker, the suprachiasmatic nucleus, where the molecular clock of a cell suffices to drive daily cycles of neuronal activity and behavior.
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