Clinical implication of centrosome amplification in plasma cell neoplasm
Wee Joo Chng,Greg J. Ahmann,Greg J. Ahmann,Kim Henderson,Kim Henderson,Rafael Santana-Davila,Rafael Santana-Davila,Philip R. Greipp,Philip R. Greipp,Morie A. Gertz,Morie A. Gertz,Martha Q. Lacy,Martha Q. Lacy,Angela Dispenzieri,Angela Dispenzieri,Shaji Kumar,Shaji Kumar,S. Vincent Rajkumar,S. Vincent Rajkumar,John A. Lust,John A. Lust,Robert A. Kyle,Robert A. Kyle,Steven R. Zeldenrust,Steven R. Zeldenrust,Suzanne R. Hayman,Suzanne R. Hayman,Rafael Fonseca,Rafael Fonseca +28 more
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TL;DR: Using immunofluorescent staining, centrosome amplification was detected in 67% of monoclonal gammopathies, and gene expression data correlated well with IF-detected centrosomes, allowing us to derive a gene expression-basedCentrosome index (CI) as a surrogate for centrosomal amplification.
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About: This article is published in Blood. The article was published on 01 May 2006. and is currently open access. The article focuses on the topics: Centrosome & Monoclonal gammopathy of undetermined significance.
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Rafael Fonseca,P L Bergsagel,Johannes Drach,John D. Shaughnessy,Norma C. Gutiérrez,Alexander Keith Stewart,Gareth J. Morgan,B Van Ness,Marta Chesi,Stephane Minvielle,Antonino Neri,Bart Barlogie,W. M. Kuehl,Peter Liebisch,Faith E. Davies,Selina Chen-Kiang,Brian G.M. Durie,Ruben D. Carrasco,Orhan Sezer,Tony Reiman,Linda M. Pilarski,Hervé Avet-Loiseau,Hervé Avet-Loiseau +22 more
TL;DR: In this paper, the authors proposed a framework for the classification of myeloma subtypes and provided recommendations for genetic testing, which needs to be incorporated into daily clinical practice and also as an essential component of all ongoing and future clinical trials.
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SPOTLIGHT REVIEW International Myeloma Working Group molecular classification of multiple myeloma: spotlight review
R Fonseca,P L Bergsagel,Johannes Drach,John D. Shaughnessy,Norma C. Gutiérrez,Alexander Keith Stewart,G Morgan,B Van Ness,Marta Chesi,Stephane Minvielle,Antonino Neri,Bart Barlogie,W. M. Kuehl,Peter Liebisch,Faith E. Davies,Selina Chen-Kiang,Ruben D. Carrasco,Orhan Sezer,Tony Reiman,Linda M. Pilarski,Hervé Avet-Loiseau,Samuel Oschin +21 more
- 01 Jan 2009
TL;DR: It is proposed that genetic testing needs to be incorporated into daily clinical practice and also as an essential component of all ongoing and future clinical trials.
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Extramedullary disease portends poor prognosis in multiple myeloma and is over-represented in high-risk disease even in the era of novel agents
Saad Z. Usmani,Christoph Heuck,Alan Mitchell,Jackie Szymonifka,Bijay Nair,Antje Hoering,Yazan Alsayed,Sarah Waheed,Sajjad Haider,Alejandro Restrepo,Frits van Rhee,John Crowley,Bart Barlogie +12 more
TL;DR: It is shown that extramedullary disease is more prevalent in genomically defined high-risk multiple myeloma and is associated with shorter progression-free survival and overall survival, even in the era of novel agents.
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Losing balance: the origin and impact of aneuploidy in cancer
TL;DR: The progress in the understanding of the causes and effects of aneuploidy in cancer is reviewed and how, in specific contexts, aneuPLoidy can provide a growth advantage and facilitate cellular transformation is discussed.
References
Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma
P. Leif Bergsagel,W. Michael Kuehl,Fenghuang Zhan,Jeffrey R. Sawyer,Bart Barlogie,John D. Shaughnessy +5 more
TL;DR: Using gene expression profiling to identify 5 recurrent translocations, specific trisomies, and expression of cyclin D genes, MM tumors can be divided into 8 TC (translocation/cyclin D) groups that appear to be defined by early, and perhaps initiating, oncogenic events.
735
Genetics and Cytogenetics of Multiple Myeloma A Workshop Report
Rafael Fonseca,Bart Barlogie,Régis Bataille,Christian Bastard,P. Leif Bergsagel,Marta Chesi,Faith E. Davies,Johannes Drach,Philip R. Greipp,Ilan R. Kirsch,W. Michael Kuehl,Jesus M. Hernandez,Stephane Minvielle,Linda M. Pilarski,John D. Shaughnessy,A. Keith Stewart,Hervé Avet-Loiseau,Hervé Avet-Loiseau +17 more
TL;DR: This summary describes the consensus recommendations arising from that meeting with special emphasis on novel genetic observations and Gene expression platforms capable of detecting many of the genetic aberrations found in the clonal cells of myeloma.
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•Journal Article
Centrosome Defects and Genetic Instability in Malignant Tumors
German Pihan,Aruna Purohit,Janice Wallace,Hans Knecht,Bruce A. Woda,Peter J. Quesenberry,Stephen J. Doxsey +6 more
TL;DR: Centrosomes in nearly all tumors and tumor-derived cell lines were atypical in shape, size, and composition and were often present in multiple copies, suggesting they may contribute to genetic instability in cancer.
Centrosome composition and microtubule anchoring mechanisms.
TL;DR: The role of the centriole pair in controlling both the structural stability and the activity of theCentrosome in animal cells is now becoming clearer and the potential use of the generational asymmetry of centrosomes or spindle pole bodies for controlling cell polarity is growing theme.
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Centrosome amplification drives chromosomal instability in breast tumor development.
Wilma L. Lingle,Susan L. Barrett,Vivian Negron,Antonino B. D'Assoro,Kelly Boeneman,Wanguo Liu,Clark M. Whitehead,Carol Reynolds,Jeffrey L. Salisbury +8 more
TL;DR: It is demonstrated that independent aspects of centrosome amplification correlate with chromosomal instability and loss of tissue differentiation and may be involved in tumor development and progression and that the centrosomes may be a potential target for cancer therapy.
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