Journal Article10.1097/MAJ.0B013E31812DFE1E
Cisplatin Nephrotoxicity: A Review
TL;DR: Understanding the mechanisms of injury has led to multiple approaches to prevention and potential approaches to treatment and the experimental approaches in these studies with cisplatin are potentially applicable to other drugs causing renal dysfunction.
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About: This article is published in The American Journal of the Medical Sciences. The article was published on 01 Aug 2007. The article focuses on the topics: Cisplatin & Nephrotoxicity.
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Citations
Tempol, a superoxide dismutase mimetic agent, ameliorates cisplatin-induced nephrotoxicity through alleviation of mitochondrial dysfunction in mice.
TL;DR: The potential role of tempol is highlighted in inhibiting cisplatin-induced nephrotoxicity without affecting its antitumor activity via amelioration of oxidative stress and mitochondrial dysfunction.
Involvement of gold and silver nanoparticles in lung cancer nanomedicines: A review
TL;DR: The use of nanoparticles in cancer therapies has spawned a new field of study known as cancer nanomedicines as discussed by the authors , which is an astonishment to see the benefits and application of metal nanoparticles over traditional therapy.
The Nephroprotective Effects of α-Bisabolol in Cisplatin-Induced Acute Kidney Injury in Mice
Nur Elena Zaaba,Sumaya Beegam,Ozaz Elzaki,Javed Yasin,Bilal Mohamed Nemmar,Badreldin H. Ali,Ernest Adeghate,Abderrahim Nemmar +7 more
TL;DR: Data suggest that α-Bisabolol exerts a protective action against CP-induced nephrotoxicity by mitigating inflammation and oxidative stress through the inhibition of NFκB activation.
Recent Findings on the Mechanism of Cisplatin-Induced Renal Cytotoxicity and Therapeutic Potential of Natural Compounds
Dahae Lee,Sungyoul Choi,Noriko Yamabe,Ki Hyun Kim,Ki Sung Kang +4 more
TL;DR: Recent research highlights the therapeutic potential of natural compounds, particularly triterpenoids, in mitigating cisplatin-induced renal cytotoxicity through antioxidant and anti-inflammatory pathways, offering a promising approach to reduce nephrotoxicity in cancer patients.
Urinary metabolic profiling of cisplatin nephrotoxicity and nephroprotective effects of Orthosiphon stamineus leaves elucidated by 1H NMR spectroscopy.
Raghunath Pariyani,Intan Safinar Ismail,Amalina Ahmad Azam,Alfi Khatib,Faridah Abas,Khozirah Shaari,Hazilawati Hamza +6 more
TL;DR: This research denotes the first comprehensive analysis to identify the effects of OS extracts on cisplatin nephrotoxicity in rats and identified that OSFE had higher concentrations of the secondary metabolites such as caffeic acid, chlorogenic acid, protocatechuic acid and orthosiphol, among others, whereas, OSAE was characterized byHigher concentrations of acetate, lactate, succinic acid, valine and phosphatidylcholine.
References
Adriamycin: the role of lipid peroxidation in cardiac toxicity and tumor response
Charles E. Myers,William McGuire,Robert H. Liss,Ina Ifrim,Karen R. Grotzinger,Robert C. Young +5 more
TL;DR: The results suggest that adriamycin has at least two mechanisms of tissue damage: one, which involves lipid peroxidation, is blocked by tocopherol and results in cardiac toxicity; the other, which consists of binding to DNA, is not antagonized by toCophero and is responsible for tumor response.
1.1K
TNF-α mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity
TL;DR: The results indicate cisplatin nephrotoxicity is characterized by activation of proinflammatory cytokines and chemokines and TNF-alpha appears to play a central role in the activation of this cytokine response and also in the pathogenesis of cisPlatin renal injury.
Acute renal failure: definitions, diagnosis, pathogenesis, and therapy
TL;DR: The epidemiology and pathophysiology of ARF are discussed, including the vascular, tubular, and inflammatory perturbations and implications for potential future therapies to decrease the high mortality.
Cellular accumulation of the anticancer agent cisplatin: a review.
Dennis P. Gately,S. B. Howell +1 more
TL;DR: This paper reviews the existing data on the mechanism of DDP accumulation and develops the postulate that some component of transport occurs through a gated ion channel.
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Cisplatin Nephrotoxicity Is Critically Mediated via the Human Organic Cation Transporter 2
Giuliano Ciarimboli,Thomas Ludwig,Detlef Lang,Hermann Pavenstädt,Hermann Koepsell,Hans-Jürgen Piechota,Jörg Haier,Ulrich Jaehde,Jochen Zisowsky,Eberhard Schlatter +9 more
TL;DR: It is demonstrated that uptake of cis-platin is mediated by hOCT2 in renal proximal tubules, explaining its organ-specific toxicity.