Journal Article10.1097/MAJ.0B013E31812DFE1E
Cisplatin Nephrotoxicity: A Review
TL;DR: Understanding the mechanisms of injury has led to multiple approaches to prevention and potential approaches to treatment and the experimental approaches in these studies with cisplatin are potentially applicable to other drugs causing renal dysfunction.
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About: This article is published in The American Journal of the Medical Sciences. The article was published on 01 Aug 2007. The article focuses on the topics: Cisplatin & Nephrotoxicity.
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Citations
•Journal Article
Effect of Andrographis paniculata on cisplatin induced renal histopathology in Wistar albino rats
TL;DR: Prior administration of AP inhibited the CP induced kidney injury and has good prophylactic effect, indicating that the study indicated that the role of ethanolic extract of Andrographis paniculata in preventing cisplatin induced histopathological changes in renal tissue was evaluated.
Speculation of the Cytotoxic Effect of Cisplatin Either Necrosis or Apoptosis and the Possible Antagonist Protective Role of Acetyl L-Carnitine, In vitro Study
TL;DR: CisPlatin has a devastating effect on dental pulp tissues via both the apoptosis and necrosis pathways and L-Carnitine had a protective effect against the cytotoxicity of Cisplatin.
Cu(II)-bis(benzoylacetonate) complexes as potential inhibitors for tubulin polymerization: synthesis, crystal structure, spectral characterization, HSA, DFT, molecular docking studies, and antioxidant activity
Abdenour Guerraoui,Meriem Goudjil,Amel Djedouani,Amani Direm,Abdelhalim Boussaa,Douniazed Hannachi,Elvira Fantechi,G. Ruani,A. Boumaza +8 more
Nefrotoxicidad asociada a la combinación de cisplatino e inhibidores del punto de control inmunitario. Estudio histopatológico
Julia Ausin,Javier Tascón,Alfredo G. Casanova,Laura Vicente-Vicente,Ana Isabel Morales,Marta Prieto +5 more
TL;DR: La combinación de cisplatino con inhibidores del punto de control inmunitario causa daño renal tubular en ratas.
References
Adriamycin: the role of lipid peroxidation in cardiac toxicity and tumor response
Charles E. Myers,William McGuire,Robert H. Liss,Ina Ifrim,Karen R. Grotzinger,Robert C. Young +5 more
TL;DR: The results suggest that adriamycin has at least two mechanisms of tissue damage: one, which involves lipid peroxidation, is blocked by tocopherol and results in cardiac toxicity; the other, which consists of binding to DNA, is not antagonized by toCophero and is responsible for tumor response.
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TNF-α mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity
TL;DR: The results indicate cisplatin nephrotoxicity is characterized by activation of proinflammatory cytokines and chemokines and TNF-alpha appears to play a central role in the activation of this cytokine response and also in the pathogenesis of cisPlatin renal injury.
Acute renal failure: definitions, diagnosis, pathogenesis, and therapy
TL;DR: The epidemiology and pathophysiology of ARF are discussed, including the vascular, tubular, and inflammatory perturbations and implications for potential future therapies to decrease the high mortality.
Cellular accumulation of the anticancer agent cisplatin: a review.
Dennis P. Gately,S. B. Howell +1 more
TL;DR: This paper reviews the existing data on the mechanism of DDP accumulation and develops the postulate that some component of transport occurs through a gated ion channel.
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Cisplatin Nephrotoxicity Is Critically Mediated via the Human Organic Cation Transporter 2
Giuliano Ciarimboli,Thomas Ludwig,Detlef Lang,Hermann Pavenstädt,Hermann Koepsell,Hans-Jürgen Piechota,Jörg Haier,Ulrich Jaehde,Jochen Zisowsky,Eberhard Schlatter +9 more
TL;DR: It is demonstrated that uptake of cis-platin is mediated by hOCT2 in renal proximal tubules, explaining its organ-specific toxicity.