Journal Article10.1097/MAJ.0B013E31812DFE1E
Cisplatin Nephrotoxicity: A Review
TL;DR: Understanding the mechanisms of injury has led to multiple approaches to prevention and potential approaches to treatment and the experimental approaches in these studies with cisplatin are potentially applicable to other drugs causing renal dysfunction.
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About: This article is published in The American Journal of the Medical Sciences. The article was published on 01 Aug 2007. The article focuses on the topics: Cisplatin & Nephrotoxicity.
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Citations
The in vitro and in vivo anticancer effect of β-2-himachalen-6-ol isolated from the Lebanese Daucus carota spp. carota.
Hamid E. Daaboul
- 28 Feb 2019
TL;DR: It is established that HC is a potent and relatively safe anticancer compound that induces apoptosis through the inhibition of the MAPK/Erk and PI3K/ Akt pathways.
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Length effect of methoxy poly(ethylene oxide)-b-[poly(ε-caprolactone)-g-poly(methacrylic acid)] copolymers on cisplatin delivery.
TL;DR: MPCL-g-pMAA particles are non-cytotoxic to CRL-5802 cells but the cisplatin-loaded MPCL- g-pMAAs particles show profound cell-killing ability, and is a potential carrier for drug delivery systems.
6
Comparison between the effects of one-day treatment regimen with cisplatin on renal function and various biochemical parameters in patients with gastric and lung cancer compared with two-days divided cisplatin treatment regimen
TL;DR: The divided administration of cisplatin reduces the nephrotoxic and hypokalemia effects of this drug, however it had not significant influence on hypomagnesemia, hypocalcaemia, and hyperuricemia.
6
Paradoxical Effect of Grape Pomace Extract on Cisplatin-Induced Acute Kidney Injury in Rats
Maria Neag,Calin Mitre,Andrei Otto Mitre,Vlad Morhan,Adrian Catinean,Emil Claudiu Botan,Carmen Stanca Melincovici,Dana Muntean,Anca Dana Buzoianu +8 more
TL;DR: The results indicate that the GE did not have a protective effect on cisplatin-induced nephrotoxicity; on the contrary, GE accentuated the toxic effect of cisPlatin.
6
References
Adriamycin: the role of lipid peroxidation in cardiac toxicity and tumor response
Charles E. Myers,William McGuire,Robert H. Liss,Ina Ifrim,Karen R. Grotzinger,Robert C. Young +5 more
TL;DR: The results suggest that adriamycin has at least two mechanisms of tissue damage: one, which involves lipid peroxidation, is blocked by tocopherol and results in cardiac toxicity; the other, which consists of binding to DNA, is not antagonized by toCophero and is responsible for tumor response.
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TNF-α mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity
TL;DR: The results indicate cisplatin nephrotoxicity is characterized by activation of proinflammatory cytokines and chemokines and TNF-alpha appears to play a central role in the activation of this cytokine response and also in the pathogenesis of cisPlatin renal injury.
Acute renal failure: definitions, diagnosis, pathogenesis, and therapy
TL;DR: The epidemiology and pathophysiology of ARF are discussed, including the vascular, tubular, and inflammatory perturbations and implications for potential future therapies to decrease the high mortality.
Cellular accumulation of the anticancer agent cisplatin: a review.
Dennis P. Gately,S. B. Howell +1 more
TL;DR: This paper reviews the existing data on the mechanism of DDP accumulation and develops the postulate that some component of transport occurs through a gated ion channel.
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Cisplatin Nephrotoxicity Is Critically Mediated via the Human Organic Cation Transporter 2
Giuliano Ciarimboli,Thomas Ludwig,Detlef Lang,Hermann Pavenstädt,Hermann Koepsell,Hans-Jürgen Piechota,Jörg Haier,Ulrich Jaehde,Jochen Zisowsky,Eberhard Schlatter +9 more
TL;DR: It is demonstrated that uptake of cis-platin is mediated by hOCT2 in renal proximal tubules, explaining its organ-specific toxicity.