Journal Article10.1038/S41569-019-0167-4
Circadian rhythms and the molecular clock in cardiovascular biology and disease.
369
TL;DR: The authors suggest how circadian rhythms can be exploited, such as in chronotherapy, or targeted therapeutically, by exploiting or altering molecular time to improve existing therapies and develop novel ones.
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Abstract: The Earth turns on its axis every 24 h; almost all life on the planet has a mechanism - circadian rhythmicity - to anticipate the daily changes caused by this rotation. The molecular clocks that control circadian rhythms are being revealed as important regulators of physiology and disease. In humans, circadian rhythms have been studied extensively in the cardiovascular system. Many cardiovascular functions, such as endothelial function, thrombus formation, blood pressure and heart rate, are now known to be regulated by the circadian clock. Additionally, the onset of acute myocardial infarction, stroke, arrhythmias and other adverse cardiovascular events show circadian rhythmicity. In this Review, we summarize the role of the circadian clock in all major cardiovascular cell types and organs. Second, we discuss the role of circadian rhythms in cardiovascular physiology and disease. Finally, we postulate how circadian rhythms can serve as a therapeutic target by exploiting or altering molecular time to improve existing therapies and develop novel ones.
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References
The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator.
Nicolas Preitner,Francesca Damiola,Luis-Lopez-Molina,J. Zakany,Denis Duboule,Urs Albrecht,Ueli Schibler +6 more
TL;DR: The orphan nuclear receptor REV-ERBalpha is identified as the major regulator of cyclic Bmal1 transcription, and constitutes a molecular link through which components of the negative limb drive antiphasic expression of component of the positive limb.
2.2K
A circadian gene expression atlas in mammals: Implications for biology and medicine
TL;DR: High-resolution multiorgan expression data is generated showing that nearly half of all genes in the mouse genome oscillate with circadian rhythm somewhere in the body, and the majority of best-selling drugs and World Health Organization essential medicines directly target the products of rhythmic genes.
2.1K
A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells
TL;DR: The treatment of cultured rat-1 fibroblasts or H35 hepatoma cells with high concentrations of serum induces the circadian expression of various genes whose transcription also oscillates in living animals, and thus mimics light-induced immediate-early gene expression in the suprachiasmatic nucleus.
2K
Circadian variation in the frequency of onset of acute myocardial infarction
James E. Muller,Peter Stone,Zoltan G. Turi,John D. Rutherford,Charles A. Czeisler,Corette B. Parker,W. K. Poole,Eugene R. Passamani,Robert Roberts,Thomas L. Robertson +9 more
TL;DR: If coronary arteries become vulnerable to occlusion when the intima covering an atherosclerotic plaque is disrupted, the circadian timing of myocardial infarction may result from a variation in the tendency to thrombosis.
1.9K
Entrainment of the Circadian Clock in the Liver by Feeding
TL;DR: It is demonstrated that feeding cycles can entrain the liver independently of the SCN and the light cycle, and the need to reexamine the mammalian circadian hierarchy is suggested, raising the possibility that peripheral circadian oscillators like those in the liver may be coupled to theSCN primarily through rhythmic behavior, such as feeding.
1.8K