Circadian Clock Interaction with HIF1α Mediates Oxygenic Metabolism and Anaerobic Glycolysis in Skeletal Muscle
Clara Bien Peek,Daniel C. Levine,Jonathan Cedernaes,Akihiko Taguchi,Yumiko Kobayashi,Stacy J. Tsai,Nicolle A. Bonar,Maureen McNulty,Kathryn Moynihan Ramsey,Joseph Bass +9 more
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TL;DR: The results reveal bidirectional interactions between circadian and HIF pathways that influence metabolic adaptation to hypoxia.
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About: This article is published in Cell Metabolism. The article was published on 10 Jan 2017. and is currently open access. The article focuses on the topics: Circadian clock & CLOCK.
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Citations
Oxygen and Carbon Dioxide Rhythms Are Circadian Clock Controlled and Differentially Directed by Behavioral Signals
Yaarit Adamovich,Benjamin Ladeuix,Jonathan Sobel,Gal Manella,Adi Neufeld-Cohen,Mohammad H. Assadi,Marina Golik,Yael Kuperman,Ariel Tarasiuk,Maarten P. Koeners,Gad Asher +10 more
TL;DR: It is found that daily rhythms in oxygen and carbon dioxide are clock controlled and that time-restricted feeding restores their rhythmicity in clock-deficient mice and support a potential role for carbon dioxide in phase resetting peripheral clocks upon feeding.
The Role of Circadian Clock Genes in Critical Illness: The Potential Role of Translational Clock Gene Therapies for Targeting Inflammation, Mitochondrial Function, and Muscle Mass in Intensive Care
Joanna Poole,David W. Ray +1 more
TL;DR: This review explores the rationale and evidence for the importance of the circadian clock in surviving critical illness and represents exciting opportunities for translational therapy in intensive care, which is currently lacking.
Ticking time bombs: connections between circadian clocks and cancer.
TL;DR: Several molecular mechanistic connections have been described in which clock proteins participate in sensing DNA damage, modulating DNA repair, and influencing the ubiquitination and degradation of key players in oncogenesis (c-MYC) and tumor suppression (p53).
Out of breath, out of time: interactions between HIF and circadian rhythms.
TL;DR: This review will cover recently identified relationships between HIF and proteins of the circadian clock and understanding the molecular mechanisms regulating these overlapping pathways may open up new strategies for drug discovery.
Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease.
Gang Wu,Yin Yeng Lee,Yin Yeng Lee,Evelyn M Gulla,Andrew S. Potter,Joseph A. Kitzmiller,Marc D. Ruben,Nathan Salomonis,Nathan Salomonis,JA Whitsett,Lauren J. Francey,John B. Hogenesch,David F. Smith +12 more
TL;DR: In this article, the effects of intermittent hypoxia (IH) on the HIF-responsive pathways in the lungs of mice were investigated. And they found that exposure to IH would lead to cell-specific up and downregulation of diverse expression pathways.
References
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
TL;DR: Hypoxia-inducible factor 1 (HIF-1) is found in mammalian cells cultured under reduced O2 tension and is necessary for transcriptional activation mediated by the erythropoietin gene enhancer in hypoxic cells.
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Central and Peripheral Circadian Clocks in Mammals
TL;DR: An emerging view for the adaptive significance of circadian clocks is their fundamental role in orchestrating metabolism.
Circadian Integration of Metabolism and Energetics
Joseph Bass,Joseph S. Takahashi +1 more
TL;DR: Advances in understanding the interrelationship among circadian disruption, sleep deprivation, obesity, and diabetes are reviewed and implications for rational therapeutics for these conditions are reviewed.
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