Circadian Clock Interaction with HIF1α Mediates Oxygenic Metabolism and Anaerobic Glycolysis in Skeletal Muscle

TL;DR: Circadian medicine holds promise for improving stroke outcomes by modulating the timing of treatment and understanding the interplay between chronobiology and cerebrovascular disease.

TL;DR: The findings demonstrate that multiple timepoint collections are needed in future studies due to the innate existence of temporal oscillations observed in the bovine placenta, and may indicate limited transmission and synchronization of maternal and fetal temporal variations in transcript abundance.

TL;DR: The role of clock genes in skeletal muscle function and the importance of physical exercise as a potent synchronizing stimulus for the skeletal muscle molecular clock are discussed.

TL;DR: In this paper, a review of the recent investigations on the interconnected roles of circadian clock oscillations, redox oscillations and hypoxia in cancer is presented, highlighting the gating of the hypoxic signaling pathway by the two oscillatory systems.

TL;DR: HIF plays a central role in the transcriptional response to changes in oxygen availability and is modulated by FIH1-mediated asparagine hydroxylation, and HIF-modulatory drugs are now being developed for diverse diseases.

TL;DR: Oxygen homeostasis represents an organizing principle for understanding metazoan evolution, development, physiology, and pathobiology and rapid progress is being made in elucidating homeostatic roles of HIFs in many physiological systems, determining pathological consequences of H IF dysregulation in chronic diseases, and investigating potential targeting of Hifs for therapeutic purposes.

TL;DR: An emerging view for the adaptive significance of circadian clocks is their fundamental role in orchestrating metabolism.

TL;DR: Advances in understanding the interrelationship among circadian disruption, sleep deprivation, obesity, and diabetes are reviewed and implications for rational therapeutics for these conditions are reviewed.