Chronic Obstructive Pulmonary Disease: Safety and Tolerability of Hyperpolarized 129Xe MR Imaging in Healthy Volunteers and Patients
Bastiaan Driehuys,Santiago Martinez-Jimenez,Zackary I. Cleveland,Gregory Metz,Denise Beaver,John Nouls,S. Sivaram Kaushik,Rafael Firszt,Christine Willis,Kevin T. Kelly,Jan Wolber,Monica Kraft,H. Page McAdams +12 more
TL;DR: Inhalation of hyperpolarized xenon 129 (129)Xe is well tolerated in healthy subjects and in those with mild or moderate COPD, and subjects do experience mild, transient, xenon-related symptoms, consistent with its known anesthetic properties.
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Abstract: While the majority of subjects experienced mild transient symptoms such as dizziness, paresthesia, euphoria, and hypoesthesia, a detailed assessment of vital signs, electrocardiograms, physical and neurologic examination results, and laboratory test results showed that inhalation of multiple 1-L volumes of undiluted hyperpolarized 129Xe was well tolerated in healthy subjects and those with mild or moderate chronic obstructive pulmonary disease.
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Citations
Single-breath clinical imaging of hyperpolarized (129)Xe in the airspaces, barrier, and red blood cells using an interleaved 3D radial 1-point Dixon acquisition.
S. Sivaram Kaushik,Scott H. Robertson,Matthew S. Freeman,Mu He,Kevin T. Kelly,Justus E. Roos,Craig R. Rackley,W. Michael Foster,H. Page McAdams,Bastiaan Driehuys +9 more
TL;DR: A clinically feasible 1‐point Dixon, three‐dimensional radial acquisition strategy to create isotropic 3D MR images of 129Xe in the airspaces, barrier, and red blood cells (RBCs) in a single breath is developed and tested.
Quantitative analysis of hyperpolarized 129Xe ventilation imaging in healthy volunteers and subjects with chronic obstructive pulmonary disease
Rohan S. Virgincar,Zackary I. Cleveland,S. Sivaram Kaushik,Matthew S. Freeman,John Nouls,Gary P. Cofer,Santiago Martinez-Jimenez,Mu He,Monica Kraft,Jan Wolber,Jan Wolber,H. Page McAdams,Bastiaan Driehuys +12 more
TL;DR: V ventilation histograms and their associated CVs distinguished between subjects with COPD with similar ventilation defect scores, but visibly different ventilation patterns, and heterogeneity was analyzed using the coefficient of variation (CV).
Методы получения поляризованного ксенона для магнитно-резонансной томографии (обзор)
01 Jan 2022
TL;DR: A review of experimental studies and design developments of devices for obtaining nuclear-spin hyperpolarized 129Xe by optical pumping of rubidium vapor with subsequent spin exchange with noble gas isotope atoms is presented in this article .
Nichtinvasive funktionelle Lungenbildgebung mit hyperpolarisiertem Xenon
Mariia Anikeeva,Maitreyi Sangal,Oliver Speck,Graham Norquay,M. Zuhayra,Ulf Lützen,Josh Peters,Olav Jansen,Jan-Bernd Hövener +8 more
TL;DR: In this paper , the Lungen-MRT with hyperpolarisiertem Xenon-129 (Xe-MRT) is dargestellt. But, the Xe-mRt erlaubt einzigartige wertvolle Einblicke in die Mikrostruktur und Funktion der Lunge, einschließlich des Gasaustauschs with roten Blutkörperchen.
Noninvasive functional lung imaging with hyperpolarized xenon
Mariia Anikeeva,Maitreyi Sangal,Oliver Speck,Graham Norquay,Maaz Zuhayra,Ulf Lützen,Josh Peters,Olav Jansen,Jan-Bernd Hövener +8 more
TL;DR: Noninvasive lung imaging with hyperpolarized xenon-129 (Xe-MRT) enhances lung microstructure and function insights, including gas exchange, through 100,000-fold signal amplification, enabling 3D visualization of ventilation, microstructure, and gas transfer in under a minute.
References
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TL;DR: It is shown that 129Xe gas can be used for high-resolution MRI when the nuclear-spin polarization of the atoms is increased by laser optical pumping and spin exchange, which produces hyperpolarized 129xe, in which the magnetization is enhanced by a factor of about 105.
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TL;DR: The physics underlying the optical pumping process, imaging strategies coping with the nonequilibrium polarization, and effects of the alveolar microstructure on relaxation and diffusion of the noble gases are outlined.
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High‐volume production of laser‐polarized 129Xe
TL;DR: In this paper, a method for producing several liters of nuclear spin polarized 129Xe gas via spin exchange with an optically pumped Rb vapor was described for the continued development of magnetic resonance imaging using spin-polarized 129 Xe.
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James R. MacFall,H C Charles,R.D. Black,H. Middleton,J. C. Swartz,Brian Saam,Bastiaan Driehuys,Christopher J. Erickson,William Happer,Gordon D. Cates,G. A. Johnson,Carl E. Ravin +11 more
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TL;DR: A design for a spin-exchange optical pumping system to produce large quantities of highly polarized 129Xe through the long-lived van der Waals molecules at low pressure, combined with a high flow rate, results in large production rates of hyperpolarized xenon.
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